Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy.
Here we present our progress in inducing an ectopic brown adipose tissue (BAT) phenotype in skeletal muscle (SKM) as a potential gene therapy for obesity and its comorbidities. We used ultrasound-targeted microbubble destruction (UTMD), a novel targeted, non-viral approach to gene therapy, to delive...
| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/18915/1/30072816 |