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Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy.

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Here we present our progress in inducing an ectopic brown adipose tissue (BAT) phenotype in skeletal muscle (SKM) as a potential gene therapy for obesity and its comorbidities. We used ultrasound-targeted microbubble destruction (UTMD), a novel targeted, non-viral approach to gene therapy, to delive...

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Detalles Bibliográficos
Autores principales: Chen, Shuyuan, Bastarrachea, Raúl A., Shen, Jin Song, Laviada Nagel, Antonio, Rodríguez Ayala, Ernesto, Nava González, Edna Judith, Huang, Pintong, DeFronzo, Ralph A., Kent, Jack W., Grayburn, Paul A.
Formato: Artículo
Lenguaje:inglés
Publicado: 2018
Materias:
R Medicina en General
Acceso en línea:http://eprints.uanl.mx/18915/1/30072816

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