Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns
Objective: Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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2016
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| Online Access: | http://eprints.uanl.mx/29196/1/1068.pdf |
| _version_ | 1842097097770270720 |
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| author | Treviño Garza, Consuelo Estrada Zúñiga, Cynthia M. Mancillas Adame, Leonardo Guadalupe Villarreal Martínez, Laura Villarreal Pérez, Jesús Z. Rodríguez Balderrama, Isaías Montes Tapia, Fernando F. De la O. Cavazos, Manuel E. |
| author_facet | Treviño Garza, Consuelo Estrada Zúñiga, Cynthia M. Mancillas Adame, Leonardo Guadalupe Villarreal Martínez, Laura Villarreal Pérez, Jesús Z. Rodríguez Balderrama, Isaías Montes Tapia, Fernando F. De la O. Cavazos, Manuel E. |
| author_sort | Treviño Garza, Consuelo |
| collection | Repositorio Institucional |
| description | Objective: Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-α) levels improve weight gain prediction during the first three months of life.
Methods: Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-α were measured by multiplex immunoassay in a subsample of 86 healthy term newborns.
Results: Leptin levels significantly predicted weight gain at 3 months of followup (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life.
Conclusion: Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-α to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint. |
| format | Article |
| id | eprints-29196 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| record_format | eprints |
| spelling | eprints-291962025-08-27T18:00:00Z http://eprints.uanl.mx/29196/ Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns Treviño Garza, Consuelo Estrada Zúñiga, Cynthia M. Mancillas Adame, Leonardo Guadalupe Villarreal Martínez, Laura Villarreal Pérez, Jesús Z. Rodríguez Balderrama, Isaías Montes Tapia, Fernando F. De la O. Cavazos, Manuel E. RJ Pediatría Objective: Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-α) levels improve weight gain prediction during the first three months of life. Methods: Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-α were measured by multiplex immunoassay in a subsample of 86 healthy term newborns. Results: Leptin levels significantly predicted weight gain at 3 months of followup (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life. Conclusion: Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-α to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint. 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/29196/1/1068.pdf http://eprints.uanl.mx/29196/1.haspreviewThumbnailVersion/1068.pdf Treviño Garza, Consuelo y Estrada Zúñiga, Cynthia M. y Mancillas Adame, Leonardo Guadalupe y Villarreal Martínez, Laura y Villarreal Pérez, Jesús Z. y Rodríguez Balderrama, Isaías y Montes Tapia, Fernando F. y De la O. Cavazos, Manuel E. (2016) Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns. Journal of Clinical Research in Pediatric Endocrinology, 8 (3). pp. 321-324. ISSN 13085727 http://doi.org/10.4274/jcrpe.2693 doi:10.4274/jcrpe.2693 |
| spellingShingle | RJ Pediatría Treviño Garza, Consuelo Estrada Zúñiga, Cynthia M. Mancillas Adame, Leonardo Guadalupe Villarreal Martínez, Laura Villarreal Pérez, Jesús Z. Rodríguez Balderrama, Isaías Montes Tapia, Fernando F. De la O. Cavazos, Manuel E. Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns |
| title_full | Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns |
| title_fullStr | Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns |
| title_full_unstemmed | Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns |
| title_short | Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns |
| title_sort | adding multiple adipokines into the model do not improve weight gain prediction by leptin levels in newborns |
| topic | RJ Pediatría |
| url | http://eprints.uanl.mx/29196/1/1068.pdf |
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