Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways
Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of a...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Multidisciplinary Digital Publishing Institute
2020
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/28057/7/28057.pdf |
| _version_ | 1835349258504503296 |
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| author | Arredondo Mendoza, Gerardo Ismael Jiménez Salas, Zacarías Guzmán de la Garza, Francisco Javier Solís Pérez, Elizabeth López Cabanillas Lomelí, Manuel González Martínez, Blanca Edelia Campos Góngora, Eduardo |
| author_facet | Arredondo Mendoza, Gerardo Ismael Jiménez Salas, Zacarías Guzmán de la Garza, Francisco Javier Solís Pérez, Elizabeth López Cabanillas Lomelí, Manuel González Martínez, Blanca Edelia Campos Góngora, Eduardo |
| author_sort | Arredondo Mendoza, Gerardo Ismael |
| collection | Repositorio Institucional |
| description | Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of angiotensin II and the level of bradykinin, produced by the kallikrein-kinin system.
Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, light-headedness or hyperkalemia) to specific drug molecular structure (skin rash, neutropenia and tasting disorders) or due to associated pathologies in the patients (it has been considered a possible nephrotoxic effect when ACEIs are administered in combination with angiotensin receptor blockers, in patients that present comorbidities as diabetes, acute kidney injury or chronic kidney disease). Therefore, it is necessary the searching for new products with ACEI activity that do not produce side effects. Interestingly, species of the plant genus Salvia have been found to possess hypotensive effects. In the present study, we analyzed the effects of the ethanolic extract of Salvia hispanica L. seeds (EESH) on the expression of genes involved in pathways regulating HT. Administration of EESH to hypertensive rats inhibited the angiotensin-converting enzyme (ACE) activity along with a decrease in Ace and elevation of Agtr1a and Nos3 gene expression, as compared to that in healthy rats. Moreover, these results were similar to those observed with captopril, an antihypertensive drug used as a control. No significant change in the expression of Bdkrb2 gene was observed in the different groups of rats. To conclude, our results
demonstrate that EESH regulates blood pressure (BP) in hypertensive rats through transcriptionally regulating the expression of genes that participate in different pathways involving ACE. |
| format | Article |
| id | eprints-28057 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | eprints |
| spelling | eprints-280572025-06-17T16:22:49Z http://eprints.uanl.mx/28057/ Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways Arredondo Mendoza, Gerardo Ismael Jiménez Salas, Zacarías Guzmán de la Garza, Francisco Javier Solís Pérez, Elizabeth López Cabanillas Lomelí, Manuel González Martínez, Blanca Edelia Campos Góngora, Eduardo RC Medicina Interna, Psiquiatría, Neurología Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of angiotensin II and the level of bradykinin, produced by the kallikrein-kinin system. Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, light-headedness or hyperkalemia) to specific drug molecular structure (skin rash, neutropenia and tasting disorders) or due to associated pathologies in the patients (it has been considered a possible nephrotoxic effect when ACEIs are administered in combination with angiotensin receptor blockers, in patients that present comorbidities as diabetes, acute kidney injury or chronic kidney disease). Therefore, it is necessary the searching for new products with ACEI activity that do not produce side effects. Interestingly, species of the plant genus Salvia have been found to possess hypotensive effects. In the present study, we analyzed the effects of the ethanolic extract of Salvia hispanica L. seeds (EESH) on the expression of genes involved in pathways regulating HT. Administration of EESH to hypertensive rats inhibited the angiotensin-converting enzyme (ACE) activity along with a decrease in Ace and elevation of Agtr1a and Nos3 gene expression, as compared to that in healthy rats. Moreover, these results were similar to those observed with captopril, an antihypertensive drug used as a control. No significant change in the expression of Bdkrb2 gene was observed in the different groups of rats. To conclude, our results demonstrate that EESH regulates blood pressure (BP) in hypertensive rats through transcriptionally regulating the expression of genes that participate in different pathways involving ACE. Multidisciplinary Digital Publishing Institute 2020-08-26 Article PeerReviewed text en cc_by http://eprints.uanl.mx/28057/7/28057.pdf http://eprints.uanl.mx/28057/7.haspreviewThumbnailVersion/28057.pdf Arredondo Mendoza, Gerardo Ismael y Jiménez Salas, Zacarías y Guzmán de la Garza, Francisco Javier y Solís Pérez, Elizabeth y López Cabanillas Lomelí, Manuel y González Martínez, Blanca Edelia y Campos Góngora, Eduardo (2020) Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways. Molecules, 25 (17). pp. 3875-3886. ISSN 1420-3049 http://doi.org/10.3390/molecules25173875 doi:10.3390/molecules25173875 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Arredondo Mendoza, Gerardo Ismael Jiménez Salas, Zacarías Guzmán de la Garza, Francisco Javier Solís Pérez, Elizabeth López Cabanillas Lomelí, Manuel González Martínez, Blanca Edelia Campos Góngora, Eduardo Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways |
| title_full | Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways |
| title_fullStr | Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways |
| title_full_unstemmed | Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways |
| title_short | Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways |
| title_sort | ethanolic extract of salvia hispanica l regulates blood pressure by modulating the expression of genes involved in bp regulatory pathways |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/28057/7/28057.pdf |
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