Copper Induces Damage, Oxidative Stress and Cell Death in Endothelium of Chronic Intoxicated Wistar Rats
Reactive Oxygen Species (ROS) are part of the functional balance of various systems, they can generate cellular damage by oxidative stress associated with disease processes such as atherosclerosis, cardiovascular disease, diabetes, and aging. Some studies report that copper induces damage to the en...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Spanish / Castilian |
| Published: |
2022
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| Online Access: | http://eprints.uanl.mx/25666/1/241.pdf |
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| author | Fernández Rodarte, Bernardo Alfonso Soto Domínguez, Adolfo González Navarro, Alejandro Mellado Ayala, Maximiliano Piña Mendoza, Edgar Rodríguez Rocha, Humberto Montes de Oca Luna, Roberto Guerra Leal, Jesús Dante |
| author_facet | Fernández Rodarte, Bernardo Alfonso Soto Domínguez, Adolfo González Navarro, Alejandro Mellado Ayala, Maximiliano Piña Mendoza, Edgar Rodríguez Rocha, Humberto Montes de Oca Luna, Roberto Guerra Leal, Jesús Dante |
| author_sort | Fernández Rodarte, Bernardo Alfonso |
| collection | Repositorio Institucional |
| description | Reactive Oxygen Species (ROS) are part of the functional balance of various systems, they can generate cellular
damage by oxidative stress associated with disease processes such as atherosclerosis, cardiovascular disease, diabetes, and aging. Some studies report that copper induces damage to the endothelium, which could be associated with cardiovascular pathologies. This study was an experimental comparative, prospective, longitudinal, and controlled clinical trial in a murine animal model. Twenty-four male
Wistar rats were included, the distribution of the groups was time-depending chronic exposition to copper, and a control group. Results show gradual alterations in the groups treated with copper: areas with loss of the endothelium, signs of disorganization of smooth muscle
fibers in the tunica media, as well as areas with the fragmentation of the elastic sheets. A significant statistical difference was observed in the active- Caspase-3 analysis expression in the aortic endothelium and endothelium of the capillaries and arterioles of the lung between the control group vs 300 ppm of copper. Expression of eNOS was detected in the endothelium of the aorta and vessels of the lung. Our study shows histological changes in the walls of the great vessels of intoxicated rats with copper, and the increment of inflammatory cells
in the alveoli of the study model, mainly at a high dose of copper exposition. These results will be useful to understand more about the mediators involved in the effect of copper over endothelium and cardiovascular diseases in chronic intoxication in humans |
| format | Article |
| id | eprints-25666 |
| institution | UANL |
| language | Spanish / Castilian |
| publishDate | 2022 |
| record_format | eprints |
| spelling | eprints-256662024-03-04T16:56:19Z http://eprints.uanl.mx/25666/ Copper Induces Damage, Oxidative Stress and Cell Death in Endothelium of Chronic Intoxicated Wistar Rats Fernández Rodarte, Bernardo Alfonso Soto Domínguez, Adolfo González Navarro, Alejandro Mellado Ayala, Maximiliano Piña Mendoza, Edgar Rodríguez Rocha, Humberto Montes de Oca Luna, Roberto Guerra Leal, Jesús Dante RS Farmacia y Materia Médica Reactive Oxygen Species (ROS) are part of the functional balance of various systems, they can generate cellular damage by oxidative stress associated with disease processes such as atherosclerosis, cardiovascular disease, diabetes, and aging. Some studies report that copper induces damage to the endothelium, which could be associated with cardiovascular pathologies. This study was an experimental comparative, prospective, longitudinal, and controlled clinical trial in a murine animal model. Twenty-four male Wistar rats were included, the distribution of the groups was time-depending chronic exposition to copper, and a control group. Results show gradual alterations in the groups treated with copper: areas with loss of the endothelium, signs of disorganization of smooth muscle fibers in the tunica media, as well as areas with the fragmentation of the elastic sheets. A significant statistical difference was observed in the active- Caspase-3 analysis expression in the aortic endothelium and endothelium of the capillaries and arterioles of the lung between the control group vs 300 ppm of copper. Expression of eNOS was detected in the endothelium of the aorta and vessels of the lung. Our study shows histological changes in the walls of the great vessels of intoxicated rats with copper, and the increment of inflammatory cells in the alveoli of the study model, mainly at a high dose of copper exposition. These results will be useful to understand more about the mediators involved in the effect of copper over endothelium and cardiovascular diseases in chronic intoxication in humans 2022 Article PeerReviewed text es cc_by_nc_nd http://eprints.uanl.mx/25666/1/241.pdf http://eprints.uanl.mx/25666/1.haspreviewThumbnailVersion/241.pdf Fernández Rodarte, Bernardo Alfonso y Soto Domínguez, Adolfo y González Navarro, Alejandro y Mellado Ayala, Maximiliano y Piña Mendoza, Edgar y Rodríguez Rocha, Humberto y Montes de Oca Luna, Roberto y Guerra Leal, Jesús Dante (2022) Copper Induces Damage, Oxidative Stress and Cell Death in Endothelium of Chronic Intoxicated Wistar Rats. Int. J. Morphology, 40 (1). pp. 10-17. http://www.intjmorphol.com/es/ |
| spellingShingle | RS Farmacia y Materia Médica Fernández Rodarte, Bernardo Alfonso Soto Domínguez, Adolfo González Navarro, Alejandro Mellado Ayala, Maximiliano Piña Mendoza, Edgar Rodríguez Rocha, Humberto Montes de Oca Luna, Roberto Guerra Leal, Jesús Dante Copper Induces Damage, Oxidative Stress and Cell Death in Endothelium of Chronic Intoxicated Wistar Rats |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Copper Induces Damage, Oxidative Stress and Cell Death
in Endothelium of Chronic Intoxicated Wistar Rats |
| title_full | Copper Induces Damage, Oxidative Stress and Cell Death
in Endothelium of Chronic Intoxicated Wistar Rats |
| title_fullStr | Copper Induces Damage, Oxidative Stress and Cell Death
in Endothelium of Chronic Intoxicated Wistar Rats |
| title_full_unstemmed | Copper Induces Damage, Oxidative Stress and Cell Death
in Endothelium of Chronic Intoxicated Wistar Rats |
| title_short | Copper Induces Damage, Oxidative Stress and Cell Death
in Endothelium of Chronic Intoxicated Wistar Rats |
| title_sort | copper induces damage oxidative stress and cell death in endothelium of chronic intoxicated wistar rats |
| topic | RS Farmacia y Materia Médica |
| url | http://eprints.uanl.mx/25666/1/241.pdf |
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