| Sumario: | The incidence of acute kidney injury (AKI) in hospitalized patients with COVID-19 is
broad and ranges from 0.5 to 29% according to early reports from China and Italy [1, 2]. A
recent multicenter retrospective cohort in New York showed a higher incidence (37%) and
mortality (35%). AKI was primarily seen in COVID-19 patients with respiratory failure; 89.7%
of patients who were on mechanical ventilation developed AKI as compared to just 21.7% of
non-ventilated patients. Furthermore, 96.8% of patients who required renal replacement
therapy (RRT) were on ventilators [3]. From these first reports, AKI emerges at the same time
as the acute respiratory distress syndrome, and the development of AKI is usually found in
patients who progress to phase 3 of the extra-pulmonary systemic hyper-inflammation
syndrome [4]. Hirsch et al. [3] reported that up to 37.3% of AKI cases occurred within the first
24 h of hospital admission, and AKI frequently coincides with the development of the hyperinflammation
phase
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