| Summary: | Introduction: Information about the possible effects of cutaneous immune-mediated diseases (cIMDs) on male
sexual function and reproduction is scarce. Factors known to impair sexual health and reproduction, such as
inflammation, medication use, and hypogonadism, can be present in a significant proportion of male patients
with cIMD.
Objectives: To systematically review the literature for the influence of paternal cIMD on many aspects of male
sexual and reproductive health, such as sexual function, reproductive hormones, fertility, and pregnancy and
offspring outcomes.
Methods: A systematic literature search was performed. The searches combined keywords regarding male sexual
function and fertility, pregnancy outcomes, and offspring's health with a list of cIMDs.
Results: The majority of the identified studies included patients with psoriasis (22 of 27), and sexual function was
the most common outcome of interest (20 of 27). For patients diagnosed with psoriasis, the prevalence of male sexual
dysfunction reported in these studies ranged from 34 to 81%. Hypogonadism in patients with psoriasis was reported
in 2 of 3 studies. Sperm analysis abnormalities in patients with psoriasis were reported in 3 of 4 studies. No information
about the effect of paternal disease on pregnancy and offspring outcomes was identified.
Conclusions: Disease activity in psoriasis might play an important role in the development of sexual
dysfunction, hypogonadism, and abnormal sperm quality. For the other cIMD included in this review, there is
insufficient information regarding male sexual and reproductive health to draw firm conclusions. More research is
needed to understand the association between cIMD and impaired male sexual and reproductive health.
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