CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico
Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different po...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2020
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| Acceso en línea: | http://eprints.uanl.mx/20088/1/1-s2.0-S0365059620300921-main.pdf |
| _version_ | 1824415744759169024 |
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| author | Salinas Santander, Mauricio Andrés Cantú Salinas, Cristina Susana Ocampo Candiani, Jorge Suarez Valencia, Victor de Jesus Ramirez Guerrero, Jennifer Guadalupe Sánchez Domínguez, Celia Nohemí |
| author_facet | Salinas Santander, Mauricio Andrés Cantú Salinas, Cristina Susana Ocampo Candiani, Jorge Suarez Valencia, Victor de Jesus Ramirez Guerrero, Jennifer Guadalupe Sánchez Domínguez, Celia Nohemí |
| author_sort | Salinas Santander, Mauricio Andrés |
| collection | Repositorio Institucional |
| description | Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss
around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative
regulator of T-cell response, have been associated with a predisposition to autoimmune
diseases in different populations; however, the involvement of these genetic variants in the
development of AA is controversial.
Objective: The present study evaluated the potential association of two CTLA4 gene variants
with alopecia areata in a Mexican population.
Methods: We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and
100 healthy control participants through PCR-RFLP.
Results: No statistical difference was observed for either of the gene variants regarding
allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05).Study limitations: Small sample size of patients and the data were obtained from NortheastMexico population.Conclusion: The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factorfor the development of alopecia areata in the analyzed Mexican population |
| format | Article |
| id | eprints-20088 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| record_format | eprints |
| spelling | eprints-200882022-03-05T16:03:22Z http://eprints.uanl.mx/20088/ CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico Salinas Santander, Mauricio Andrés Cantú Salinas, Cristina Susana Ocampo Candiani, Jorge Suarez Valencia, Victor de Jesus Ramirez Guerrero, Jennifer Guadalupe Sánchez Domínguez, Celia Nohemí RL Dermatología Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial. Objective: The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population. Methods: We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP. Results: No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05).Study limitations: Small sample size of patients and the data were obtained from NortheastMexico population.Conclusion: The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factorfor the development of alopecia areata in the analyzed Mexican population 2020 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/20088/1/1-s2.0-S0365059620300921-main.pdf http://eprints.uanl.mx/20088/1.haspreviewThumbnailVersion/1-s2.0-S0365059620300921-main.pdf Salinas Santander, Mauricio Andrés y Cantú Salinas, Cristina Susana y Ocampo Candiani, Jorge y Suarez Valencia, Victor de Jesus y Ramirez Guerrero, Jennifer Guadalupe y Sánchez Domínguez, Celia Nohemí (2020) CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico. Anais brasileiros de dermatologia, 95 (3). pp. 283-288. ISSN 0365-0596 http://doi.org/10.1016/J.ABD.2020.03.001 doi:10.1016/J.ABD.2020.03.001 |
| spellingShingle | RL Dermatología Salinas Santander, Mauricio Andrés Cantú Salinas, Cristina Susana Ocampo Candiani, Jorge Suarez Valencia, Victor de Jesus Ramirez Guerrero, Jennifer Guadalupe Sánchez Domínguez, Celia Nohemí CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico |
| title_full | CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico |
| title_fullStr | CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico |
| title_full_unstemmed | CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico |
| title_short | CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico |
| title_sort | ctla4 49ag rs231775 and ct60 rs3087243 gene variants are not associated with alopecia areata in a mexican population from monterrey mexico |
| topic | RL Dermatología |
| url | http://eprints.uanl.mx/20088/1/1-s2.0-S0365059620300921-main.pdf |
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