CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico
Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different po...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | http://eprints.uanl.mx/20088/1/1-s2.0-S0365059620300921-main.pdf |
| Summary: | Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss
around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative
regulator of T-cell response, have been associated with a predisposition to autoimmune
diseases in different populations; however, the involvement of these genetic variants in the
development of AA is controversial.
Objective: The present study evaluated the potential association of two CTLA4 gene variants
with alopecia areata in a Mexican population.
Methods: We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and
100 healthy control participants through PCR-RFLP.
Results: No statistical difference was observed for either of the gene variants regarding
allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05).Study limitations: Small sample size of patients and the data were obtained from NortheastMexico population.Conclusion: The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factorfor the development of alopecia areata in the analyzed Mexican population |
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