Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy.
Here we present our progress in inducing an ectopic brown adipose tissue (BAT) phenotype in skeletal muscle (SKM) as a potential gene therapy for obesity and its comorbidities. We used ultrasound-targeted microbubble destruction (UTMD), a novel targeted, non-viral approach to gene therapy, to delive...
Main Authors: | Chen, Shuyuan, Bastarrachea, Raúl A., Shen, Jin Song, Laviada Nagel, Antonio, Rodríguez Ayala, Ernesto, Nava González, Edna Judith, Huang, Pintong, DeFronzo, Ralph A., Kent, Jack W., Grayburn, Paul A. |
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Format: | Article |
Language: | English |
Published: |
2018
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Subjects: | |
Online Access: | http://eprints.uanl.mx/18915/1/30072816 |
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