Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design

plasmid cDNA contructs encoding a gene cocktail with BMP7/ PRDM16/PPARGC1A incorporated within microbubbles and intravenously delivered into their left thigh. Controls received UTMD with plasmids driving a DsRed reporter gene. An ultrasound transducer was directed to the thigh to disrupt the mic...

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Detalles Bibliográficos

Autores principales:	Bastarrachea, Raúl A., Chen, Jiaxi, Kent, Jack W., Nava González, Edna Judith, Rodríguez Ayala, Ernesto, Daadi, Marcel M., Jorge, Barbara, Laviada Molina, Hugo A., Comuzzie, Anthony G., Chen, Shuyuan, Grayburn, Paul A.
Formato:	Artículo
Lenguaje:	inglés
Publicado:	2017
Materias:	RA Aspectos Públicos de la Medicina
Acceso en línea:	http://eprints.uanl.mx/18859/1/4.pdf