Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design
Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be due to variation in the capacity to manage a nutritional load. We examined the genomic basis of postprandial metabolism. Our main...
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| Format: | Article |
| Language: | English |
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2018
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| Online Access: | http://eprints.uanl.mx/18853/1/12.pdf |
| _version_ | 1824415365631836160 |
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| author | Bastarrachea, Raúl A. Laviada Molina, Hugo A. Nava González, Edna Judith Leal Berumen, Irene Escudero Lourdes, Claudia Escalante Araiza, Fabiola Peschard, Vanessa Giselle Veloz Garza, Rosa A. Haack, Karin Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Buenfil Rello, Fatima A. Gonzalez Ramirez, Lucia Janssen Aguilar, Reinhard Lopez Muñoz, Ricardo Perez Cetina, Fernanda Gaytan Saucedo, Janeth F. Vaquera, Zoila Cornejo Barrera, Judith Castillo Pineda, Juan Carlos Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno González López, Laura Salinas Osornio, Rocío A. Valencia Rendón, Melesio E. Angeles Chimal, José Santa Olalla Tapia, Jesús Remes Troche, José M. Valdovinos Chávez, Salvador B. Huerta Ávila, Eira E. Han, Xianlin Orozco, Lorena Rodríguez Ayala, Ernesto Weintraub, Susan Gallegos Cabriales, Esther Carlota Cole, Shelley A. Kent, Jack W. |
| author_facet | Bastarrachea, Raúl A. Laviada Molina, Hugo A. Nava González, Edna Judith Leal Berumen, Irene Escudero Lourdes, Claudia Escalante Araiza, Fabiola Peschard, Vanessa Giselle Veloz Garza, Rosa A. Haack, Karin Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Buenfil Rello, Fatima A. Gonzalez Ramirez, Lucia Janssen Aguilar, Reinhard Lopez Muñoz, Ricardo Perez Cetina, Fernanda Gaytan Saucedo, Janeth F. Vaquera, Zoila Cornejo Barrera, Judith Castillo Pineda, Juan Carlos Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno González López, Laura Salinas Osornio, Rocío A. Valencia Rendón, Melesio E. Angeles Chimal, José Santa Olalla Tapia, Jesús Remes Troche, José M. Valdovinos Chávez, Salvador B. Huerta Ávila, Eira E. Han, Xianlin Orozco, Lorena Rodríguez Ayala, Ernesto Weintraub, Susan Gallegos Cabriales, Esther Carlota Cole, Shelley A. Kent, Jack W. |
| author_sort | Bastarrachea, Raúl A. |
| collection | Repositorio Institucional |
| description | Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be due to variation in the capacity to manage a nutritional load. We examined the genomic basis of postprandial metabolism. Our main purpose was to introduce the GEMM Family Study (Genetics of Metabolic Diseases in Mexico) as a multi-center study carrying out an ongoing recruitment of healthy urban adults. Each participant received a mixed meal challenge and provided a 5-hours’ time course series of blood, buffy coat specimens for DNA isolation, and adipose tissue (ADT)/skeletal muscle (SKM) biopsies at fasting and 3 h after the meal. A comprehensive profiling, including metabolomic signatures in blood and transcriptomic and proteomic profiling in SKM and ADT, was performed to describe tendencies for variation in postprandial response. Our data generation methods showed preliminary trends indicating that by characterizing the dynamic properties of biomarkers with metabolic activity and analyzing multi-OMICS data it could be possible, with this methodology and research design, to identify early trends for molecular biology systems and genes involved in the fasted and fed states. |
| format | Article |
| id | eprints-18853 |
| institution | UANL |
| language | English |
| publishDate | 2018 |
| record_format | eprints |
| spelling | eprints-188532024-03-06T15:08:58Z http://eprints.uanl.mx/18853/ Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design Bastarrachea, Raúl A. Laviada Molina, Hugo A. Nava González, Edna Judith Leal Berumen, Irene Escudero Lourdes, Claudia Escalante Araiza, Fabiola Peschard, Vanessa Giselle Veloz Garza, Rosa A. Haack, Karin Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Buenfil Rello, Fatima A. Gonzalez Ramirez, Lucia Janssen Aguilar, Reinhard Lopez Muñoz, Ricardo Perez Cetina, Fernanda Gaytan Saucedo, Janeth F. Vaquera, Zoila Cornejo Barrera, Judith Castillo Pineda, Juan Carlos Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno González López, Laura Salinas Osornio, Rocío A. Valencia Rendón, Melesio E. Angeles Chimal, José Santa Olalla Tapia, Jesús Remes Troche, José M. Valdovinos Chávez, Salvador B. Huerta Ávila, Eira E. Han, Xianlin Orozco, Lorena Rodríguez Ayala, Ernesto Weintraub, Susan Gallegos Cabriales, Esther Carlota Cole, Shelley A. Kent, Jack W. RA Aspectos Públicos de la Medicina Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be due to variation in the capacity to manage a nutritional load. We examined the genomic basis of postprandial metabolism. Our main purpose was to introduce the GEMM Family Study (Genetics of Metabolic Diseases in Mexico) as a multi-center study carrying out an ongoing recruitment of healthy urban adults. Each participant received a mixed meal challenge and provided a 5-hours’ time course series of blood, buffy coat specimens for DNA isolation, and adipose tissue (ADT)/skeletal muscle (SKM) biopsies at fasting and 3 h after the meal. A comprehensive profiling, including metabolomic signatures in blood and transcriptomic and proteomic profiling in SKM and ADT, was performed to describe tendencies for variation in postprandial response. Our data generation methods showed preliminary trends indicating that by characterizing the dynamic properties of biomarkers with metabolic activity and analyzing multi-OMICS data it could be possible, with this methodology and research design, to identify early trends for molecular biology systems and genes involved in the fasted and fed states. 2018-11-02 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18853/1/12.pdf http://eprints.uanl.mx/18853/1.haspreviewThumbnailVersion/12.pdf Bastarrachea, Raúl A. y Laviada Molina, Hugo A. y Nava González, Edna Judith y Leal Berumen, Irene y Escudero Lourdes, Claudia y Escalante Araiza, Fabiola y Peschard, Vanessa Giselle y Veloz Garza, Rosa A. y Haack, Karin y Martínez Hernández, Angélica y Barajas Olmos, Francisco M. y Molina Segui, Fernanda y Buenfil Rello, Fatima A. y Gonzalez Ramirez, Lucia y Janssen Aguilar, Reinhard y Lopez Muñoz, Ricardo y Perez Cetina, Fernanda y Gaytan Saucedo, Janeth F. y Vaquera, Zoila y Cornejo Barrera, Judith y Castillo Pineda, Juan Carlos y Murillo Ramirez, Areli y Diaz Tena, Sara P. y Figueroa Nuñez, Benigno y González López, Laura y Salinas Osornio, Rocío A. y Valencia Rendón, Melesio E. y Angeles Chimal, José y Santa Olalla Tapia, Jesús y Remes Troche, José M. y Valdovinos Chávez, Salvador B. y Huerta Ávila, Eira E. y Han, Xianlin y Orozco, Lorena y Rodríguez Ayala, Ernesto y Weintraub, Susan y Gallegos Cabriales, Esther Carlota y Cole, Shelley A. y Kent, Jack W. (2018) Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design. Genes, 9 (11). p. 532. ISSN 2073-4425 http://doi.org/10.3390/genes9110532 doi:10.3390/genes9110532 |
| spellingShingle | RA Aspectos Públicos de la Medicina Bastarrachea, Raúl A. Laviada Molina, Hugo A. Nava González, Edna Judith Leal Berumen, Irene Escudero Lourdes, Claudia Escalante Araiza, Fabiola Peschard, Vanessa Giselle Veloz Garza, Rosa A. Haack, Karin Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Buenfil Rello, Fatima A. Gonzalez Ramirez, Lucia Janssen Aguilar, Reinhard Lopez Muñoz, Ricardo Perez Cetina, Fernanda Gaytan Saucedo, Janeth F. Vaquera, Zoila Cornejo Barrera, Judith Castillo Pineda, Juan Carlos Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno González López, Laura Salinas Osornio, Rocío A. Valencia Rendón, Melesio E. Angeles Chimal, José Santa Olalla Tapia, Jesús Remes Troche, José M. Valdovinos Chávez, Salvador B. Huerta Ávila, Eira E. Han, Xianlin Orozco, Lorena Rodríguez Ayala, Ernesto Weintraub, Susan Gallegos Cabriales, Esther Carlota Cole, Shelley A. Kent, Jack W. Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design |
| title_full | Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design |
| title_fullStr | Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design |
| title_full_unstemmed | Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design |
| title_short | Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design |
| title_sort | deep multi omics and multi tissue characterization in a pre and postprandial state in human volunteers the gemm family study research design |
| topic | RA Aspectos Públicos de la Medicina |
| url | http://eprints.uanl.mx/18853/1/12.pdf |
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