| Summary: | Guided  Bone  Regeneration  (GBR)  is  a  surgical  procedure  that  consists  in  the  use  of  barrier  membranes  to  cover  bone  defects  caused by trauma, periodontal disease and other pathologies. These barriers allow the proliferation of bone cells, and prevent the invasion  of  the  defect  by  non-osteogenic  cells  (connective  and  epithelium)  in  patients  with  a  lack  of  horizontal  and/or  vertical  bone.  This  process  is  essential  for  the  successful  dental  implant  placement.  Additive  manufacturing  (AM)  is  emerging  as  an  important  tool  for  biomedical  applications,  especially  for  regenerative  medicine  and  tissue  engineering.  This  paper  proposes  a  process  chain  for  the  fabrication  of  a  custom  barrier  from  cone  beam  computed  tomography  (CBCT)  as  Digital  Imaging  and  Communication  in Medicine  (DICOM)  files  obtained  from  a  patient  with  vertical  bone  resorption  of  the  anterior  maxilla.  DICOM files have been processed with Invesalius 3.0 to obtain the tridimensional (3D) anatomy of the region of interest. This 3D  model  was  cleaned,  fixed,  and  smoothed.  The  prototyped  model  of  the  patient’s  bone  defect  was  further  processed  in  Rhinoceros  to  offer  a  3D  architecture  for  cell  growth.  To  obtain  information  of  the  thermal  and  mechanical  properties  a  finite  element method (FEM) was assessed. The prototype obtained was produced with fused deposition modeling (FDM) an additive manufacturing technology 
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