Microglia activation due to obesity programs metabolic failure leading to type two diabetes
Obesity is an energy metabolism disorder that increases susceptibility to the development of metabolic diseases. Recently, it has been described that obese subjects have a phenotype of chronic inflammation in organs that are metabolically relevant for glucose homeostasis and energy. Altered expressio...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
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| Acceso en línea: | http://eprints.uanl.mx/18259/1/549.pdf |
| _version_ | 1824415188927905792 |
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| author | Maldonado Ruiz, Roger Alexis Montalvo Martínez, Larisa Jajaira Fuentes Mera, Lizeth Camacho Morales, Alberto |
| author_facet | Maldonado Ruiz, Roger Alexis Montalvo Martínez, Larisa Jajaira Fuentes Mera, Lizeth Camacho Morales, Alberto |
| author_sort | Maldonado Ruiz, Roger Alexis |
| collection | Repositorio Institucional |
| description | Obesity is an energy metabolism disorder that increases susceptibility to the development of metabolic diseases. Recently, it has been described that obese subjects have a phenotype of chronic inflammation in organs that are metabolically relevant for glucose homeostasis and energy. Altered expression of immune system molecules such as interleukins IL-1, IL-6, IL-18, tumor necrosis factor alpha (TNF-α), serum amyloid A (SAA), and plasminogen activator inhibitor-1 (PAI-1), among others, has been associated with the development of chronic inflammation in obesity. Chronic inflammation modulates the development of metabolic-related comorbidities like metabolic syndrome (insulin resistance, glucose tolerance, hypertension and hyperlipidemia). Recent evidence suggests that microglia activation in the central nervous system (CNS) is a priority in the deregulation of energy homeostasis and promotes increased glucose levels. This review will cover the most significant advances that explore the molecular signals during microglia activation and inflammatory stage in the brain in the context of obesity, and its influence on the development of metabolic syndrome and type two diabetes. |
| format | Article |
| id | eprints-18259 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-182592024-03-05T15:25:10Z http://eprints.uanl.mx/18259/ Microglia activation due to obesity programs metabolic failure leading to type two diabetes Maldonado Ruiz, Roger Alexis Montalvo Martínez, Larisa Jajaira Fuentes Mera, Lizeth Camacho Morales, Alberto R Medicina en General RC Medicina Interna, Psiquiatría, Neurología Obesity is an energy metabolism disorder that increases susceptibility to the development of metabolic diseases. Recently, it has been described that obese subjects have a phenotype of chronic inflammation in organs that are metabolically relevant for glucose homeostasis and energy. Altered expression of immune system molecules such as interleukins IL-1, IL-6, IL-18, tumor necrosis factor alpha (TNF-α), serum amyloid A (SAA), and plasminogen activator inhibitor-1 (PAI-1), among others, has been associated with the development of chronic inflammation in obesity. Chronic inflammation modulates the development of metabolic-related comorbidities like metabolic syndrome (insulin resistance, glucose tolerance, hypertension and hyperlipidemia). Recent evidence suggests that microglia activation in the central nervous system (CNS) is a priority in the deregulation of energy homeostasis and promotes increased glucose levels. This review will cover the most significant advances that explore the molecular signals during microglia activation and inflammatory stage in the brain in the context of obesity, and its influence on the development of metabolic syndrome and type two diabetes. 2017-03-20 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18259/1/549.pdf http://eprints.uanl.mx/18259/1.haspreviewThumbnailVersion/549.pdf Maldonado Ruiz, Roger Alexis y Montalvo Martínez, Larisa Jajaira y Fuentes Mera, Lizeth y Camacho Morales, Alberto (2017) Microglia activation due to obesity programs metabolic failure leading to type two diabetes. Nutrition & Diabetes, 7 (3). pp. 1-9. ISSN 2044-4052 http://doi.org/10.1038/nutd.2017.10 doi:10.1038/nutd.2017.10 |
| spellingShingle | R Medicina en General RC Medicina Interna, Psiquiatría, Neurología Maldonado Ruiz, Roger Alexis Montalvo Martínez, Larisa Jajaira Fuentes Mera, Lizeth Camacho Morales, Alberto Microglia activation due to obesity programs metabolic failure leading to type two diabetes |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Microglia activation due to obesity programs metabolic failure leading to type two diabetes |
| title_full | Microglia activation due to obesity programs metabolic failure leading to type two diabetes |
| title_fullStr | Microglia activation due to obesity programs metabolic failure leading to type two diabetes |
| title_full_unstemmed | Microglia activation due to obesity programs metabolic failure leading to type two diabetes |
| title_short | Microglia activation due to obesity programs metabolic failure leading to type two diabetes |
| title_sort | microglia activation due to obesity programs metabolic failure leading to type two diabetes |
| topic | R Medicina en General RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/18259/1/549.pdf |
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