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Voriconazole MICs are predictive for the outcome of experimental disseminated scedosporiosis

Scedosporiosis is associated with a mortality rate of up to 90% in patients suffering from disseminated infections. Recommended first-line treatment is voriconazole, but epidemiological cut-off values and clinical breakpoints have not been determined. Objectives: To correlate voriconazole treatment...

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Bibliographic Details
Main Authors: Martin Vicente, Adela, Guarro, Josep, González González, Gloria María, Lass Flörl, Cornelia, Lackner, Michaela, Capilla, Javier
Format: Article
Language:English
Published: 2016
Subjects:
RF Otorrinolaringología: Oídos, Nariz y Garganta
Online Access:http://eprints.uanl.mx/18245/1/537.pdf
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Summary:Scedosporiosis is associated with a mortality rate of up to 90% in patients suffering from disseminated infections. Recommended first-line treatment is voriconazole, but epidemiological cut-off values and clinical breakpoints have not been determined. Objectives: To correlate voriconazole treatment response in mice suffering from disseminated scedosporiosis with MIC values determined using CLSI broth microdilution, Etest (bioMe´rieux) and disc diffusion

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