The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants
We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference between BM and PBSCs (P = 0.08). Incidence of acute...
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/18213/1/504.pdf |
| _version_ | 1824415170939584512 |
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| author | Gómez Almaguer, David Vázquez Mellado, Alberto Navarro Cabrera, Juan Ramón Abello Polo, Virginia Milovic, Vera García, Juan José Basquiera, Ana Lisa Saba, Silvia Balladares, G. Vela Ojeda, Jorge Gómez, S. Karduss Aurueta, A. Bustinza Álvarez, Adriana Requejo, Alejandro Feldman, Leonardo Jaime Pérez, José Carlos Yantorno, Sebastián Kusminsky, G. Gutiérrez Aguirre, César Homero Arbelbide, Jorge Alberto Martínez Rolon, Juliana Jarchum, Gustavo Jaimovich, Gregorio Riera, L. Pedraza Mesa, Enrique Villamizar Gómez, Francy Licet Herrera Rojas, Miguel Ángel Gamboa Alonso, M M Foncuberta, María Cecilia Rodríguez González, Guadalupe García Ruiz Esparza, Miriam América Hernández Maldonado, E. Paz Infanzón, Manuel González Lopez, Elias Eugenio Ruiz Argüelles, Guillermo José |
| author_facet | Gómez Almaguer, David Vázquez Mellado, Alberto Navarro Cabrera, Juan Ramón Abello Polo, Virginia Milovic, Vera García, Juan José Basquiera, Ana Lisa Saba, Silvia Balladares, G. Vela Ojeda, Jorge Gómez, S. Karduss Aurueta, A. Bustinza Álvarez, Adriana Requejo, Alejandro Feldman, Leonardo Jaime Pérez, José Carlos Yantorno, Sebastián Kusminsky, G. Gutiérrez Aguirre, César Homero Arbelbide, Jorge Alberto Martínez Rolon, Juliana Jarchum, Gustavo Jaimovich, Gregorio Riera, L. Pedraza Mesa, Enrique Villamizar Gómez, Francy Licet Herrera Rojas, Miguel Ángel Gamboa Alonso, M M Foncuberta, María Cecilia Rodríguez González, Guadalupe García Ruiz Esparza, Miriam América Hernández Maldonado, E. Paz Infanzón, Manuel González Lopez, Elias Eugenio Ruiz Argüelles, Guillermo José |
| author_sort | Gómez Almaguer, David |
| collection | Repositorio Institucional |
| description | We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference between BM and PBSCs (P = 0.08). Incidence of acute GvHD (aGvHD) for BM and PBSCs was 30% vs 32% (P = 0.18), and for grades III–IV was 2.6% vs 11.6% (P = 0.01). Chronic GvHD (cGvHD) between BM and PBSCs was 37% vs 59% (P = 0.002) and extensive 5% vs 23.6% (P = 0.01). OS was 74% vs 76% for BM vs PBSCs (P = 0.95). Event-free survival was superior in patients conditioned with anti-thymocyte globulin (ATG)-based regimens compared with other regimens (79% vs 61%, P = 0.001) as excessive secondary graft failure was seen with other regimens (10% vs 26%, P = 0.005) respectively. In multivariate analysis, aGvHD II–IV (hazard ratio (HR) 2.50, confidence interval (CI) 1.1–5.6, P = 0.02) and aGvHD III–IV (HR 8.3 CI 3.4–20.2, Po0.001) proved to be independent negative predictors of survival. In conclusion, BM as a source of cells and ATG-based regimens should be standard because of higher GvHD
incidence with PBSCs, although the latter combining with ATG in the conditioning regimen could be an option in selected high-risk patients |
| format | Article |
| id | eprints-18213 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| record_format | eprints |
| spelling | eprints-182132023-05-25T18:44:58Z http://eprints.uanl.mx/18213/ The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants Gómez Almaguer, David Vázquez Mellado, Alberto Navarro Cabrera, Juan Ramón Abello Polo, Virginia Milovic, Vera García, Juan José Basquiera, Ana Lisa Saba, Silvia Balladares, G. Vela Ojeda, Jorge Gómez, S. Karduss Aurueta, A. Bustinza Álvarez, Adriana Requejo, Alejandro Feldman, Leonardo Jaime Pérez, José Carlos Yantorno, Sebastián Kusminsky, G. Gutiérrez Aguirre, César Homero Arbelbide, Jorge Alberto Martínez Rolon, Juliana Jarchum, Gustavo Jaimovich, Gregorio Riera, L. Pedraza Mesa, Enrique Villamizar Gómez, Francy Licet Herrera Rojas, Miguel Ángel Gamboa Alonso, M M Foncuberta, María Cecilia Rodríguez González, Guadalupe García Ruiz Esparza, Miriam América Hernández Maldonado, E. Paz Infanzón, Manuel González Lopez, Elias Eugenio Ruiz Argüelles, Guillermo José RB Patología We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference between BM and PBSCs (P = 0.08). Incidence of acute GvHD (aGvHD) for BM and PBSCs was 30% vs 32% (P = 0.18), and for grades III–IV was 2.6% vs 11.6% (P = 0.01). Chronic GvHD (cGvHD) between BM and PBSCs was 37% vs 59% (P = 0.002) and extensive 5% vs 23.6% (P = 0.01). OS was 74% vs 76% for BM vs PBSCs (P = 0.95). Event-free survival was superior in patients conditioned with anti-thymocyte globulin (ATG)-based regimens compared with other regimens (79% vs 61%, P = 0.001) as excessive secondary graft failure was seen with other regimens (10% vs 26%, P = 0.005) respectively. In multivariate analysis, aGvHD II–IV (hazard ratio (HR) 2.50, confidence interval (CI) 1.1–5.6, P = 0.02) and aGvHD III–IV (HR 8.3 CI 3.4–20.2, Po0.001) proved to be independent negative predictors of survival. In conclusion, BM as a source of cells and ATG-based regimens should be standard because of higher GvHD incidence with PBSCs, although the latter combining with ATG in the conditioning regimen could be an option in selected high-risk patients 2016-08-22 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18213/1/504.pdf http://eprints.uanl.mx/18213/1.haspreviewThumbnailVersion/504.pdf Gómez Almaguer, David y Vázquez Mellado, Alberto y Navarro Cabrera, Juan Ramón y Abello Polo, Virginia y Milovic, Vera y García, Juan José y Basquiera, Ana Lisa y Saba, Silvia y Balladares, G. y Vela Ojeda, Jorge y Gómez, S. y Karduss Aurueta, A. y Bustinza Álvarez, Adriana y Requejo, Alejandro y Feldman, Leonardo y Jaime Pérez, José Carlos y Yantorno, Sebastián y Kusminsky, G. y Gutiérrez Aguirre, César Homero y Arbelbide, Jorge Alberto y Martínez Rolon, Juliana y Jarchum, Gustavo y Jaimovich, Gregorio y Riera, L. y Pedraza Mesa, Enrique y Villamizar Gómez, Francy Licet y Herrera Rojas, Miguel Ángel y Gamboa Alonso, M M y Foncuberta, María Cecilia y Rodríguez González, Guadalupe y García Ruiz Esparza, Miriam América y Hernández Maldonado, E. y Paz Infanzón, Manuel y González Lopez, Elias Eugenio y Ruiz Argüelles, Guillermo José (2016) The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants. Bone marrow transplantation, 52 (1). pp. 41-46. ISSN 0268-3369 http://doi.org/10.1038/bmt.2016.212 doi:10.1038/bmt.2016.212 |
| spellingShingle | RB Patología Gómez Almaguer, David Vázquez Mellado, Alberto Navarro Cabrera, Juan Ramón Abello Polo, Virginia Milovic, Vera García, Juan José Basquiera, Ana Lisa Saba, Silvia Balladares, G. Vela Ojeda, Jorge Gómez, S. Karduss Aurueta, A. Bustinza Álvarez, Adriana Requejo, Alejandro Feldman, Leonardo Jaime Pérez, José Carlos Yantorno, Sebastián Kusminsky, G. Gutiérrez Aguirre, César Homero Arbelbide, Jorge Alberto Martínez Rolon, Juliana Jarchum, Gustavo Jaimovich, Gregorio Riera, L. Pedraza Mesa, Enrique Villamizar Gómez, Francy Licet Herrera Rojas, Miguel Ángel Gamboa Alonso, M M Foncuberta, María Cecilia Rodríguez González, Guadalupe García Ruiz Esparza, Miriam América Hernández Maldonado, E. Paz Infanzón, Manuel González Lopez, Elias Eugenio Ruiz Argüelles, Guillermo José The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants |
| title_full | The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants |
| title_fullStr | The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants |
| title_full_unstemmed | The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants |
| title_short | The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants |
| title_sort | latin american experience of allografting patients with severe aplastic anaemia real world data on the impact of stem cell source and atg administration in hla identical sibling transplants |
| topic | RB Patología |
| url | http://eprints.uanl.mx/18213/1/504.pdf |
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