DNA damage in acute myeloid leukemia patients of Northern Mexico
Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA d...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
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| Acceso en línea: | http://eprints.uanl.mx/17430/1/286.pdf |
| _version_ | 1824414897175265280 |
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| author | Dávila Rodríguez, Martha Imelda Cortés Gutiérrez, Elva Irene Hernández Valdés, Roberto Guzmán Cortés, Karla De León Cantú, Rosa E. Cerda Flores, Ricardo Martín Báez de la Fuente, Enrique |
| author_facet | Dávila Rodríguez, Martha Imelda Cortés Gutiérrez, Elva Irene Hernández Valdés, Roberto Guzmán Cortés, Karla De León Cantú, Rosa E. Cerda Flores, Ricardo Martín Báez de la Fuente, Enrique |
| author_sort | Dávila Rodríguez, Martha Imelda |
| collection | Repositorio Institucional |
| description | Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy. |
| format | Article |
| id | eprints-17430 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-174302022-02-10T22:05:13Z http://eprints.uanl.mx/17430/ DNA damage in acute myeloid leukemia patients of Northern Mexico Dávila Rodríguez, Martha Imelda Cortés Gutiérrez, Elva Irene Hernández Valdés, Roberto Guzmán Cortés, Karla De León Cantú, Rosa E. Cerda Flores, Ricardo Martín Báez de la Fuente, Enrique Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy. 2017 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/17430/1/286.pdf http://eprints.uanl.mx/17430/1.haspreviewThumbnailVersion/286.pdf Dávila Rodríguez, Martha Imelda y Cortés Gutiérrez, Elva Irene y Hernández Valdés, Roberto y Guzmán Cortés, Karla y De León Cantú, Rosa E. y Cerda Flores, Ricardo Martín y Báez de la Fuente, Enrique (2017) DNA damage in acute myeloid leukemia patients of Northern Mexico. European Journal of Histochemistry, 61 (4). pp. 295-298. ISSN 1121-760X http://doi.org/10.4081/ejh.2017.2851 doi:10.4081/ejh.2017.2851 |
| spellingShingle | Dávila Rodríguez, Martha Imelda Cortés Gutiérrez, Elva Irene Hernández Valdés, Roberto Guzmán Cortés, Karla De León Cantú, Rosa E. Cerda Flores, Ricardo Martín Báez de la Fuente, Enrique DNA damage in acute myeloid leukemia patients of Northern Mexico |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | DNA damage in acute myeloid leukemia patients of Northern Mexico |
| title_full | DNA damage in acute myeloid leukemia patients of Northern Mexico |
| title_fullStr | DNA damage in acute myeloid leukemia patients of Northern Mexico |
| title_full_unstemmed | DNA damage in acute myeloid leukemia patients of Northern Mexico |
| title_short | DNA damage in acute myeloid leukemia patients of Northern Mexico |
| title_sort | dna damage in acute myeloid leukemia patients of northern mexico |
| url | http://eprints.uanl.mx/17430/1/286.pdf |
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