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DNA damage in acute myeloid leukemia patients of Northern Mexico

Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA d...

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Bibliographic Details
Main Authors: Dávila Rodríguez, Martha Imelda, Cortés Gutiérrez, Elva Irene, Hernández Valdés, Roberto, Guzmán Cortés, Karla, De León Cantú, Rosa E., Cerda Flores, Ricardo Martín, Báez de la Fuente, Enrique
Format: Article
Language:English
Published: 2017
Online Access:http://eprints.uanl.mx/17430/1/286.pdf
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Summary:Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

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