Imagen de Portada

DNA damage in acute myeloid leukemia patients of Northern Mexico

Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA d...

Descripción completa

Detalles Bibliográficos
Autores principales: Dávila Rodríguez, Martha Imelda, Cortés Gutiérrez, Elva Irene, Hernández Valdés, Roberto, Guzmán Cortés, Karla, De León Cantú, Rosa E., Cerda Flores, Ricardo Martín, Báez de la Fuente, Enrique
Formato: Artículo
Lenguaje:inglés
Publicado: 2017
Acceso en línea:http://eprints.uanl.mx/17430/1/286.pdf
Descripción
Sumario:Abstract The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

Ejemplares similares