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Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer

Abstract Background: Fluoropyrimidines form the chemotherapy backbone of advanced and metastatic colorectal cancer (CRC). These drugs are frequently associated with toxicity events that result in dose adjustments and even suspension of the treatment. The thymidylate synthase (TYMS) gene is a potenti...

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Bibliographic Details
Main Authors:	Castro Rojas, Carlos Andrés, Esparza Mota, Antonio R., Hernández Cabrera, Francisco, Romero Díaz, Víktor J., González Guerrero, Juan Francisco, Maldonado Garza, Héctor Jesús, García González, Irma S., Buenaventura Cisneros, Sergio, Sanchez Lopez, Josefina Y., Ortiz López, Rocío, Camacho Morales, Alberto, Barboza Quintana, Oralia, Rojas Martínez, Augusto
Format:	Article
Language:	English
Published:	2017
Online Access:	http://eprints.uanl.mx/17427/1/284.pdf

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