Biological Activities of Extracts from Aerial Parts of Salvia pachyphylla Epling Ex Munz

Abstract: The antioxidant, antimicrobial, antiproliferative, and enzyme inhibitory properties of five extracts from aerial parts of Salvia pachyphylla Epling ex Munz were examined to assess the prospective of this plant as a source of natural products with therapeutic potential. These properties were...

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Main Authors: Almada Taylor, Gabriela, Díaz Rubio, Laura, Salazar Aranda, Ricardo, Waksman de Torres, Noemí, Uranga Solis, Carla, Delgadillo Rodríguez, José, Ramos, Marco, Padrón, José, Hernández Martínez, Rufina, Córdova Guerrero, Iván
Format: Article
Language:English
Published: 2018
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Online Access:http://eprints.uanl.mx/15968/1/41.pdf
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Summary:Abstract: The antioxidant, antimicrobial, antiproliferative, and enzyme inhibitory properties of five extracts from aerial parts of Salvia pachyphylla Epling ex Munz were examined to assess the prospective of this plant as a source of natural products with therapeutic potential. These properties were analyzed by performing a set of standard assays. The extract obtained with dichloromethane showed the most variety of components, as they yielded promising results in all completed assays. Furthermore,theextractobtainedwithethylacetateexhibitedthegreatestantioxidantactivity,aswell as the best xanthine oxidase inhibitory activity. Remarkably, both extracts obtained with n-hexane or dichloromethane revealed significant antimicrobial activity against the Gram-positive bacteria; additionally, they showed greater antiproliferative activity against three representative cell lines of the most common types of cancers in women worldwide, and against a cell line that exemplifies cancers that typically develop drug resistance. Despite that, other extracts were less active, such as the methanolic or aqueous; their results are promising for the isolation and identification of novel bioactive molecules.