A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model
Thedevelopmentofnewnanomaterialstopromotewoundhealingisrising,becauseoftheirtopicaladministrationandeasyfunctionalizationwithmoleculesthatcanimproveandacceleratethe processofhealing.Ananocompositeofgoldnanoparticles(AuNPs)functionalizedwithcalreticulinwassynthetizedandevaluated.Theabilityofthenanoco...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2019
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| Acceso en línea: | http://eprints.uanl.mx/15814/1/16.pdf |
| _version_ | 1824414390671114240 |
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| author | Hernández Martínez, Sara Paola Rivera González, Teodoro Iván Franco Molina, Moisés Armides Juan José Bollain y Goytia de la Rosa, Juan José Martínez Sanmiguel, Juan José Zárate Triviño, Diana Ginette Rodríguez Padilla, Cristina |
| author_facet | Hernández Martínez, Sara Paola Rivera González, Teodoro Iván Franco Molina, Moisés Armides Juan José Bollain y Goytia de la Rosa, Juan José Martínez Sanmiguel, Juan José Zárate Triviño, Diana Ginette Rodríguez Padilla, Cristina |
| author_sort | Hernández Martínez, Sara Paola |
| collection | Repositorio Institucional |
| description | Thedevelopmentofnewnanomaterialstopromotewoundhealingisrising,becauseoftheirtopicaladministrationandeasyfunctionalizationwithmoleculesthatcanimproveandacceleratethe processofhealing.Ananocompositeofgoldnanoparticles(AuNPs)functionalizedwithcalreticulinwassynthetizedandevaluated.Theabilityofthenanocompositetopromoteproliferationandmigrationwasdeterminedinvitro,andinvivowoundhealingwasevaluatedusingamicemodelofdiabetesestablishedwithstreptozotocin(STZ).Invitro,thenanocompositenotaffectthecellviabilityandtheexpressionofproliferatingcellnuclearantigen(PCNA).Moreover,thenanocompositepromotestheclonogenicityof keratinocytes,endothelialcells,andfibroblasts,andacceleratesfibroblastmigration.Invivo,micetreatedwiththenanocompositepresentedsignificantlyfasterwoundhealing. Thehistologicalevaluationshowed re-epithelization and the formation of granular tissue, as well as an increase of collagen deposition.
Therefore,theseresultsconfirmtheutilityofAuNPs–calreticulinnanocompositesaspotentialtreatment forwoundhealingofdiabeticulcers |
| format | Article |
| id | eprints-15814 |
| institution | UANL |
| language | English |
| publishDate | 2019 |
| record_format | eprints |
| spelling | eprints-158142024-12-09T18:42:35Z http://eprints.uanl.mx/15814/ A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model Hernández Martínez, Sara Paola Rivera González, Teodoro Iván Franco Molina, Moisés Armides Juan José Bollain y Goytia de la Rosa, Juan José Martínez Sanmiguel, Juan José Zárate Triviño, Diana Ginette Rodríguez Padilla, Cristina Thedevelopmentofnewnanomaterialstopromotewoundhealingisrising,becauseoftheirtopicaladministrationandeasyfunctionalizationwithmoleculesthatcanimproveandacceleratethe processofhealing.Ananocompositeofgoldnanoparticles(AuNPs)functionalizedwithcalreticulinwassynthetizedandevaluated.Theabilityofthenanocompositetopromoteproliferationandmigrationwasdeterminedinvitro,andinvivowoundhealingwasevaluatedusingamicemodelofdiabetesestablishedwithstreptozotocin(STZ).Invitro,thenanocompositenotaffectthecellviabilityandtheexpressionofproliferatingcellnuclearantigen(PCNA).Moreover,thenanocompositepromotestheclonogenicityof keratinocytes,endothelialcells,andfibroblasts,andacceleratesfibroblastmigration.Invivo,micetreatedwiththenanocompositepresentedsignificantlyfasterwoundhealing. Thehistologicalevaluationshowed re-epithelization and the formation of granular tissue, as well as an increase of collagen deposition. Therefore,theseresultsconfirmtheutilityofAuNPs–calreticulinnanocompositesaspotentialtreatment forwoundhealingofdiabeticulcers 2019-07-08 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15814/1/16.pdf http://eprints.uanl.mx/15814/1.haspreviewThumbnailVersion/16.pdf Hernández Martínez, Sara Paola y Rivera González, Teodoro Iván y Franco Molina, Moisés Armides y Juan José Bollain y Goytia de la Rosa, Juan José y Martínez Sanmiguel, Juan José y Zárate Triviño, Diana Ginette y Rodríguez Padilla, Cristina (2019) A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model. Nanomaterials, 9 (1). pp. 1-16. ISSN 2079-4991 http://doi.org/10.3390/nano9010075 doi:10.3390/nano9010075 |
| spellingShingle | Hernández Martínez, Sara Paola Rivera González, Teodoro Iván Franco Molina, Moisés Armides Juan José Bollain y Goytia de la Rosa, Juan José Martínez Sanmiguel, Juan José Zárate Triviño, Diana Ginette Rodríguez Padilla, Cristina A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model |
| title_full | A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model |
| title_fullStr | A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model |
| title_full_unstemmed | A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model |
| title_short | A Novel Gold Calreticulin Nanocomposite Based on Chitosan for Wound Healing in a Diabetic Mice Model |
| title_sort | novel gold calreticulin nanocomposite based on chitosan for wound healing in a diabetic mice model |
| url | http://eprints.uanl.mx/15814/1/16.pdf |
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