| Sumario: | Thedevelopmentofnewnanomaterialstopromotewoundhealingisrising,becauseoftheirtopicaladministrationandeasyfunctionalizationwithmoleculesthatcanimproveandacceleratethe processofhealing.Ananocompositeofgoldnanoparticles(AuNPs)functionalizedwithcalreticulinwassynthetizedandevaluated.Theabilityofthenanocompositetopromoteproliferationandmigrationwasdeterminedinvitro,andinvivowoundhealingwasevaluatedusingamicemodelofdiabetesestablishedwithstreptozotocin(STZ).Invitro,thenanocompositenotaffectthecellviabilityandtheexpressionofproliferatingcellnuclearantigen(PCNA).Moreover,thenanocompositepromotestheclonogenicityof keratinocytes,endothelialcells,andfibroblasts,andacceleratesfibroblastmigration.Invivo,micetreatedwiththenanocompositepresentedsignificantlyfasterwoundhealing. Thehistologicalevaluationshowed re-epithelization and the formation of granular tissue, as well as an increase of collagen deposition.
Therefore,theseresultsconfirmtheutilityofAuNPs–calreticulinnanocompositesaspotentialtreatment forwoundhealingofdiabeticulcers
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