Neurofilamentopathy in Neurodegenerative Diseases

Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration...

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Detalles Bibliográficos
Autores principales: Liu, Quan, Xie, Fang, Alvarado Diaz, Abdiel, Smith, Mark A., Moreira, Paula I., Zhu, Xiongwei, Perry, George
Formato: Artículo
Lenguaje:inglés
Publicado: 2011
Materias:
Acceso en línea:http://eprints.uanl.mx/15057/1/677.pdf
Descripción
Sumario:Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented.