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Molecular annotation of ketol-acid reductoisomerases fromStreptomycesreveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity

The 6-phosphogluconate dehydrogenase superfamily oxidize and reduce a wide range of substrates, making their functional annotation challenging. Ketolacid reductoisomerase (KARI), encoded by the ilvC gene in branched-chain amino acids biosynthesis, is a promiscuous reductase enzyme within this supe...

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Bibliographic Details
Main Authors:	Verdel Aranda, Karina, López Cortina, Susana, Hodgson, David A., Barona Gómez, Francisco
Format:	Article
Language:	English
Published:	2014
Online Access:	http://eprints.uanl.mx/15043/1/204.pdf

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