Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases
Acute lymphoblastic leukemia is the most common malignancy in pediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood. Some acute lymphoblastic leukemia patients may initially present with pancytopenia and a hypoplastic bon...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2012
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| Acceso en línea: | http://eprints.uanl.mx/15024/1/622.pdf |
| _version_ | 1824414228153368576 |
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| author | Villarreal Martínez, Laura Jaime Pérez, José Carlos Rodríguez Martínez, Marisol González Llano, Óscar Gómez Almaguer, David |
| author_facet | Villarreal Martínez, Laura Jaime Pérez, José Carlos Rodríguez Martínez, Marisol González Llano, Óscar Gómez Almaguer, David |
| author_sort | Villarreal Martínez, Laura |
| collection | Repositorio Institucional |
| description | Acute lymphoblastic leukemia is the most common malignancy in pediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood. Some acute lymphoblastic leukemia patients may initially present with pancytopenia and a hypoplastic bone marrow leading to the initial diagnosis of aplastic anemia. In most of these patients clinical improvement occurs, with normalization of the complete blood count within six months, although recovery can also develop a few weeks after initiating steroid therapy. The etiologic relationship between the aplastic anemia features and the subsequent overt development of acute lymphoblastic leukemia has not been established. We describe the cases of two children who presented with severe infection and signs and symptoms of aplastic anemia confirmed by bone marrow aspirate and bone marrow biopsy that developed acute lymphoblastic leukemia thereafter. No specific therapy for aplastic anemia was administered, nevertheless a full spontaneous recovery was observed in both cases. Acute lymphoblastic leukemia was successfully treated with standard chemotherapy, both children remaining in complete remission 16 and 17 months after their initial aplastic anemia diagnosis |
| format | Article |
| id | eprints-15024 |
| institution | UANL |
| language | English |
| publishDate | 2012 |
| record_format | eprints |
| spelling | eprints-150242019-08-20T19:55:22Z http://eprints.uanl.mx/15024/ Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases Villarreal Martínez, Laura Jaime Pérez, José Carlos Rodríguez Martínez, Marisol González Llano, Óscar Gómez Almaguer, David Acute lymphoblastic leukemia is the most common malignancy in pediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood. Some acute lymphoblastic leukemia patients may initially present with pancytopenia and a hypoplastic bone marrow leading to the initial diagnosis of aplastic anemia. In most of these patients clinical improvement occurs, with normalization of the complete blood count within six months, although recovery can also develop a few weeks after initiating steroid therapy. The etiologic relationship between the aplastic anemia features and the subsequent overt development of acute lymphoblastic leukemia has not been established. We describe the cases of two children who presented with severe infection and signs and symptoms of aplastic anemia confirmed by bone marrow aspirate and bone marrow biopsy that developed acute lymphoblastic leukemia thereafter. No specific therapy for aplastic anemia was administered, nevertheless a full spontaneous recovery was observed in both cases. Acute lymphoblastic leukemia was successfully treated with standard chemotherapy, both children remaining in complete remission 16 and 17 months after their initial aplastic anemia diagnosis 2012 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15024/1/622.pdf http://eprints.uanl.mx/15024/1.haspreviewThumbnailVersion/622.pdf Villarreal Martínez, Laura y Jaime Pérez, José Carlos y Rodríguez Martínez, Marisol y González Llano, Óscar y Gómez Almaguer, David (2012) Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases. Revista Brasileira de Hematologia e Hemoterapia, 34 (2). pp. 165-167. ISSN 1516-8484 http://doi.org/10.5581/1516-8484.20120037 doi:10.5581/1516-8484.20120037 |
| spellingShingle | Villarreal Martínez, Laura Jaime Pérez, José Carlos Rodríguez Martínez, Marisol González Llano, Óscar Gómez Almaguer, David Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases |
| title_full | Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases |
| title_fullStr | Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases |
| title_full_unstemmed | Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases |
| title_short | Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases |
| title_sort | acute lymphoblastic leukemia of childhood presenting as aplastic anemia report of two cases |
| url | http://eprints.uanl.mx/15024/1/622.pdf |
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