Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis
Objective: By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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2015
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| Online Access: | http://eprints.uanl.mx/14982/1/142.pdf |
| _version_ | 1824414211716939776 |
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| author | Jaime Pérez, José Carlos García Arellano, Gisela Méndez Ramírez, Nereida González Llano, Óscar Gómez Almaguer, David |
| author_facet | Jaime Pérez, José Carlos García Arellano, Gisela Méndez Ramírez, Nereida González Llano, Óscar Gómez Almaguer, David |
| author_sort | Jaime Pérez, José Carlos |
| collection | Repositorio Institucional |
| description | Objective: By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns.
Methods: Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0 g/dL and newborns with cord Hb <13.0 g/dL were classified as anemic. A serum ferritin <12.0g/L in women and a cord blood serum ferritin <35.0g/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis
was applied to select the cut-off points that better reflected iron stores.
Results: The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5 g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450). Most of
the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0 g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217). The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0g/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200).
Conclusion: Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns. |
| format | Article |
| id | eprints-14982 |
| institution | UANL |
| language | English |
| publishDate | 2015 |
| record_format | eprints |
| spelling | eprints-149822019-05-16T14:28:15Z http://eprints.uanl.mx/14982/ Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis Jaime Pérez, José Carlos García Arellano, Gisela Méndez Ramírez, Nereida González Llano, Óscar Gómez Almaguer, David Objective: By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns. Methods: Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0 g/dL and newborns with cord Hb <13.0 g/dL were classified as anemic. A serum ferritin <12.0g/L in women and a cord blood serum ferritin <35.0g/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis was applied to select the cut-off points that better reflected iron stores. Results: The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5 g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450). Most of the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0 g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217). The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0g/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200). Conclusion: Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns. 2015 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14982/1/142.pdf http://eprints.uanl.mx/14982/1.haspreviewThumbnailVersion/142.pdf Jaime Pérez, José Carlos y García Arellano, Gisela y Méndez Ramírez, Nereida y González Llano, Óscar y Gómez Almaguer, David (2015) Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis. Revista Brasileira de Hematologia e Hemoterapia, 37 (3). pp. 178-183. ISSN 15168484 http://doi.org/10.1016/j.bjhh.2015.02.002 doi:10.1016/j.bjhh.2015.02.002 |
| spellingShingle | Jaime Pérez, José Carlos García Arellano, Gisela Méndez Ramírez, Nereida González Llano, Óscar Gómez Almaguer, David Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis |
| title_full | Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis |
| title_fullStr | Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis |
| title_full_unstemmed | Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis |
| title_short | Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis |
| title_sort | evaluation of hemoglobin performance in the assessment of iron stores in feto maternal pairs in a high risk population receiver operating characteristic curve analysis |
| url | http://eprints.uanl.mx/14982/1/142.pdf |
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