Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia type B (B-ALL) is a neoplastic disorder with high mortality rates. The aim of this study was to validate the expression profile of 45 genes associated with signaling pathways involved in leukemia and to evaluate their association with the prognosis of B-ALL. Methods. 219...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2015
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| Acceso en línea: | http://eprints.uanl.mx/14975/1/134.pdf |
| _version_ | 1824414209330380800 |
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| author | Garza Veloz, Idalia Martínez Fierro, Margarita de la Luz Jaime Pérez, José Carlos Carrillo Sanchez, Karol Ramos Del Hoyo, Maria Guadalupe Lugo Trampe, Ángel Rojas Martínez, Augusto Gutiérrez Aguirre, César Homero González Llano, Óscar Salazar Riojas, María del Rosario Hidalgo Miranda, Alfredo Gómez Almaguer, David Ortiz López, Rocío |
| author_facet | Garza Veloz, Idalia Martínez Fierro, Margarita de la Luz Jaime Pérez, José Carlos Carrillo Sanchez, Karol Ramos Del Hoyo, Maria Guadalupe Lugo Trampe, Ángel Rojas Martínez, Augusto Gutiérrez Aguirre, César Homero González Llano, Óscar Salazar Riojas, María del Rosario Hidalgo Miranda, Alfredo Gómez Almaguer, David Ortiz López, Rocío |
| author_sort | Garza Veloz, Idalia |
| collection | Repositorio Institucional |
| description | Acute lymphoblastic leukemia type B (B-ALL) is a neoplastic disorder with high mortality rates. The aim of this study was to validate the expression profile of 45 genes associated with signaling pathways involved in leukemia and to evaluate their association with the prognosis of B-ALL. Methods. 219 samples of peripheral blood mononuclear cells obtained from 73 B-ALL patients were studied at diagnosis, four, and eight weeks after starting treatment. Gene expression was analyzed by quantitative realtime polymerase chain reaction. Results. Normalized delta Cq values of 23 genes showed differences between B-ALL and controls at diagnosis time ( |
| format | Article |
| id | eprints-14975 |
| institution | UANL |
| language | English |
| publishDate | 2015 |
| record_format | eprints |
| spelling | eprints-149752023-05-11T16:18:07Z http://eprints.uanl.mx/14975/ Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia Garza Veloz, Idalia Martínez Fierro, Margarita de la Luz Jaime Pérez, José Carlos Carrillo Sanchez, Karol Ramos Del Hoyo, Maria Guadalupe Lugo Trampe, Ángel Rojas Martínez, Augusto Gutiérrez Aguirre, César Homero González Llano, Óscar Salazar Riojas, María del Rosario Hidalgo Miranda, Alfredo Gómez Almaguer, David Ortiz López, Rocío Acute lymphoblastic leukemia type B (B-ALL) is a neoplastic disorder with high mortality rates. The aim of this study was to validate the expression profile of 45 genes associated with signaling pathways involved in leukemia and to evaluate their association with the prognosis of B-ALL. Methods. 219 samples of peripheral blood mononuclear cells obtained from 73 B-ALL patients were studied at diagnosis, four, and eight weeks after starting treatment. Gene expression was analyzed by quantitative realtime polymerase chain reaction. Results. Normalized delta Cq values of 23 genes showed differences between B-ALL and controls at diagnosis time ( 2015 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14975/1/134.pdf http://eprints.uanl.mx/14975/1.haspreviewThumbnailVersion/134.pdf Garza Veloz, Idalia y Martínez Fierro, Margarita de la Luz y Jaime Pérez, José Carlos y Carrillo Sanchez, Karol y Ramos Del Hoyo, Maria Guadalupe y Lugo Trampe, Ángel y Rojas Martínez, Augusto y Gutiérrez Aguirre, César Homero y González Llano, Óscar y Salazar Riojas, María del Rosario y Hidalgo Miranda, Alfredo y Gómez Almaguer, David y Ortiz López, Rocío (2015) Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia. Disease Markers, 2015. pp. 1-11. ISSN 0278-0240 http://doi.org/10.1155/2015/828145 doi:10.1155/2015/828145 |
| spellingShingle | Garza Veloz, Idalia Martínez Fierro, Margarita de la Luz Jaime Pérez, José Carlos Carrillo Sanchez, Karol Ramos Del Hoyo, Maria Guadalupe Lugo Trampe, Ángel Rojas Martínez, Augusto Gutiérrez Aguirre, César Homero González Llano, Óscar Salazar Riojas, María del Rosario Hidalgo Miranda, Alfredo Gómez Almaguer, David Ortiz López, Rocío Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia |
| title_full | Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia |
| title_fullStr | Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia |
| title_short | Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia |
| title_sort | identification of differentially expressed genes associated with prognosis of b acute lymphoblastic leukemia |
| url | http://eprints.uanl.mx/14975/1/134.pdf |
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