Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2015
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| Online Access: | http://eprints.uanl.mx/14972/1/131.pdf |
| _version_ | 1824414208074186752 |
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| author | Escarcena, Ricardo Pérez Meseguer, Jonathan Del Olmo, Esther Alanís Garza, Blanca Alicia Garza González, Elvira Salazar Aranda, Ricardo Waksman de Torres, Noemí |
| author_facet | Escarcena, Ricardo Pérez Meseguer, Jonathan Del Olmo, Esther Alanís Garza, Blanca Alicia Garza González, Elvira Salazar Aranda, Ricardo Waksman de Torres, Noemí |
| author_sort | Escarcena, Ricardo |
| collection | Repositorio Institucional |
| description | Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol. |
| format | Article |
| id | eprints-14972 |
| institution | UANL |
| language | English |
| publishDate | 2015 |
| record_format | eprints |
| spelling | eprints-149722021-05-07T16:42:42Z http://eprints.uanl.mx/14972/ Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis Escarcena, Ricardo Pérez Meseguer, Jonathan Del Olmo, Esther Alanís Garza, Blanca Alicia Garza González, Elvira Salazar Aranda, Ricardo Waksman de Torres, Noemí Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol. 2015 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14972/1/131.pdf http://eprints.uanl.mx/14972/1.haspreviewThumbnailVersion/131.pdf Escarcena, Ricardo y Pérez Meseguer, Jonathan y Del Olmo, Esther y Alanís Garza, Blanca Alicia y Garza González, Elvira y Salazar Aranda, Ricardo y Waksman de Torres, Noemí (2015) Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis. Molecules, 20 (4). pp. 7245-7262. ISSN 1420-3049 http://doi.org/10.3390/molecules20047245 doi:10.3390/molecules20047245 |
| spellingShingle | Escarcena, Ricardo Pérez Meseguer, Jonathan Del Olmo, Esther Alanís Garza, Blanca Alicia Garza González, Elvira Salazar Aranda, Ricardo Waksman de Torres, Noemí Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis |
| title_full | Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis |
| title_fullStr | Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis |
| title_full_unstemmed | Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis |
| title_short | Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis |
| title_sort | diterpenes synthesized from the natural serrulatane leubethanol and their in vitro activities against mycobacterium tuberculosis |
| url | http://eprints.uanl.mx/14972/1/131.pdf |
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