Odor Memory Stability after Reinnervation of the Olfactory Bulb
The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functio...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Public Library of Science
2012
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| Acceso en línea: | http://eprints.uanl.mx/14927/1/589.PDF |
| _version_ | 1824414192232300544 |
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| author | Ravel, Nadine Blanco Hernández, Eduardo Valle Leija, Pablo Zomosa Signoret, Viviana Chantal Drucker Colín, René Vidaltamayo, Román |
| author_facet | Ravel, Nadine Blanco Hernández, Eduardo Valle Leija, Pablo Zomosa Signoret, Viviana Chantal Drucker Colín, René Vidaltamayo, Román |
| author_sort | Ravel, Nadine |
| collection | Repositorio Institucional |
| description | The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain. |
| format | Article |
| id | eprints-14927 |
| institution | UANL |
| language | English |
| publishDate | 2012 |
| publisher | Public Library of Science |
| record_format | eprints |
| spelling | eprints-149272020-03-05T22:59:22Z http://eprints.uanl.mx/14927/ Odor Memory Stability after Reinnervation of the Olfactory Bulb Ravel, Nadine Blanco Hernández, Eduardo Valle Leija, Pablo Zomosa Signoret, Viviana Chantal Drucker Colín, René Vidaltamayo, Román The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain. Public Library of Science 2012 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14927/1/589.PDF http://eprints.uanl.mx/14927/1.haspreviewThumbnailVersion/589.PDF Ravel, Nadine y Blanco Hernández, Eduardo y Valle Leija, Pablo y Zomosa Signoret, Viviana Chantal y Drucker Colín, René y Vidaltamayo, Román (2012) Odor Memory Stability after Reinnervation of the Olfactory Bulb. PloS one, 7 (10). e46338. ISSN 1932-6203 http://doi.org/10.1371/journal.pone.0046338 doi:10.1371/journal.pone.0046338 |
| spellingShingle | Ravel, Nadine Blanco Hernández, Eduardo Valle Leija, Pablo Zomosa Signoret, Viviana Chantal Drucker Colín, René Vidaltamayo, Román Odor Memory Stability after Reinnervation of the Olfactory Bulb |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Odor Memory Stability after Reinnervation of the Olfactory Bulb |
| title_full | Odor Memory Stability after Reinnervation of the Olfactory Bulb |
| title_fullStr | Odor Memory Stability after Reinnervation of the Olfactory Bulb |
| title_full_unstemmed | Odor Memory Stability after Reinnervation of the Olfactory Bulb |
| title_short | Odor Memory Stability after Reinnervation of the Olfactory Bulb |
| title_sort | odor memory stability after reinnervation of the olfactory bulb |
| url | http://eprints.uanl.mx/14927/1/589.PDF |
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