Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases
There is a need for new noninvasive biomarkers (NIBMs) able to assess cholestasis and fibrosis in chronic cholestatic liver diseases (CCLDs). Tumorigenesis can arise from CCLDs. Therefore, autoantibodies to tumor-associated antigens (TAA) may be early produced in response to abnormal self-antigen ex...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/14881/1/92.pdf |
| _version_ | 1824414174943379456 |
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| author | Duval, Florent Cruz Vega, Delia Elva González Gamboa, Ivonne González Garza y Barrón, María Teresa Ponz, Fernando Sánchez, Flora Alarcón Galván, Gabriela Moreno Cuevas, Jorge E. |
| author_facet | Duval, Florent Cruz Vega, Delia Elva González Gamboa, Ivonne González Garza y Barrón, María Teresa Ponz, Fernando Sánchez, Flora Alarcón Galván, Gabriela Moreno Cuevas, Jorge E. |
| author_sort | Duval, Florent |
| collection | Repositorio Institucional |
| description | There is a need for new noninvasive biomarkers (NIBMs) able to assess cholestasis and fibrosis in chronic cholestatic liver diseases (CCLDs). Tumorigenesis can arise from CCLDs. Therefore, autoantibodies to tumor-associated antigens (TAA) may be early produced in response to abnormal self-antigen expression caused by cholestatic injury. Vascular endothelial growth factor receptor3 (VEGFR-3) has TAA potential since it is involved in cholangiocytes and lymphatic vessels proliferations during CCLDs. This study aims to detect autoantibodies directed at VEGFR-3 during bile duct ligation- (BDL-) induced cholestatic injury in rat sera
and investigate whether they could be associated with traditional markers of liver damage, cholestasis, and fibrosis. An ELISA was performed to detect anti-VEGFR-3 autoantibodies in sera of rats with different degree of liver injury and results were correlated with aminotransferases, total bilirubin, and the relative fibrotic area. Mean absorbances of anti-VEGFR-3 autoantibodies were significantly increased from week one to week five after BDL.The highest correlation was observed with total bilirubin ( |
| format | Article |
| id | eprints-14881 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| record_format | eprints |
| spelling | eprints-148812021-04-20T15:01:32Z http://eprints.uanl.mx/14881/ Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases Duval, Florent Cruz Vega, Delia Elva González Gamboa, Ivonne González Garza y Barrón, María Teresa Ponz, Fernando Sánchez, Flora Alarcón Galván, Gabriela Moreno Cuevas, Jorge E. RC Medicina Interna, Psiquiatría, Neurología RM Terapéutica, Farmacología There is a need for new noninvasive biomarkers (NIBMs) able to assess cholestasis and fibrosis in chronic cholestatic liver diseases (CCLDs). Tumorigenesis can arise from CCLDs. Therefore, autoantibodies to tumor-associated antigens (TAA) may be early produced in response to abnormal self-antigen expression caused by cholestatic injury. Vascular endothelial growth factor receptor3 (VEGFR-3) has TAA potential since it is involved in cholangiocytes and lymphatic vessels proliferations during CCLDs. This study aims to detect autoantibodies directed at VEGFR-3 during bile duct ligation- (BDL-) induced cholestatic injury in rat sera and investigate whether they could be associated with traditional markers of liver damage, cholestasis, and fibrosis. An ELISA was performed to detect anti-VEGFR-3 autoantibodies in sera of rats with different degree of liver injury and results were correlated with aminotransferases, total bilirubin, and the relative fibrotic area. Mean absorbances of anti-VEGFR-3 autoantibodies were significantly increased from week one to week five after BDL.The highest correlation was observed with total bilirubin ( 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14881/1/92.pdf http://eprints.uanl.mx/14881/1.haspreviewThumbnailVersion/92.pdf Duval, Florent y Cruz Vega, Delia Elva y González Gamboa, Ivonne y González Garza y Barrón, María Teresa y Ponz, Fernando y Sánchez, Flora y Alarcón Galván, Gabriela y Moreno Cuevas, Jorge E. (2016) Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases. Disease Markers, 2016. pp. 1-7. ISSN 0278-0240 http://doi.org/10.1155/2016/6597970 doi:10.1155/2016/6597970 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología RM Terapéutica, Farmacología Duval, Florent Cruz Vega, Delia Elva González Gamboa, Ivonne González Garza y Barrón, María Teresa Ponz, Fernando Sánchez, Flora Alarcón Galván, Gabriela Moreno Cuevas, Jorge E. Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases |
| title_full | Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases |
| title_fullStr | Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases |
| title_full_unstemmed | Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases |
| title_short | Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases |
| title_sort | detection of autoantibodies to vascular endothelial growth factor receptor 3 in bile duct ligated rats and correlations with a panel of traditional markers of liver diseases |
| topic | RC Medicina Interna, Psiquiatría, Neurología RM Terapéutica, Farmacología |
| url | http://eprints.uanl.mx/14881/1/92.pdf |
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