Cutaneous graft-versus-host disease after hematopoietic stem cell transplant - a review

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, c...

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Detalles Bibliográficos
Autores principales: Villarreal Villarreal, César Daniel, Alanis, Julio Cesar Salas, Pérez, Jose Carlos Jaime, Candiani, Jorge Ocampo
Formato: Artículo
Lenguaje:inglés
Publicado: 2016
Materias:
Acceso en línea:http://eprints.uanl.mx/14801/1/36.pdf
Descripción
Sumario:Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, clinical features, prevention and treatment of cutaneous graft-versus-host disease. We discuss various insights into the disease’s mechanisms and the different treatments for acute and chronic skin graft-versus-host disease.