| Summary: | Cancer is the second leading disease which causes major mortality and morbidity worldwide1
. In cancer therapy, it is
crucial to increase the drug specificity and drug efficacy to minimise or completely eradicate significant side-effects on
patients2
. Cancer nanotherapeutics overcome many serious drawbacks of chemotherapy such as non-specific targeting,
lower efficacy, insolubility of drug moieties in water and oral bioavailability3
. Accordingly, Superparamagnetic Iron
Oxide Nanoparticles (SPIONs) are exploited as an important nanomaterial for cancer detection as well as therapeutics4
.
Such magnetic nanoparticles (NPs) gained its momentum because of their single-domain ordering along with their
large surface to volume ratio (providing large surface area for attachment of biological entities). Hence, this property
makes them a suitable candidate as a contrast agent, drug-carrying cargo and hyperthermal agent5
.
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