Combined therapy in diabetic macular edema
Purpose: To determine the effectiveness of three different combinations for the ‘‘loading phase’’ in the treatment of diabetic macular edema (DME), using bevacizumab (BVZ), triamcinolone (TCL) and subthreshold macular photocoagulation (SMPC). Methods: Experimental, longitudinal, prospective, compara...
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| Format: | Article |
| Language: | English |
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UANL. Facultad de Medicina
2015
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| Online Access: | http://eprints.uanl.mx/11641/1/S1665579615000459_S300_en.pdf |
| _version_ | 1824413412986191872 |
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| author | González Cortés, Jesús Hernán Toledo Negrete, Juan José Butrón Valdez, K. Zapata Elizondo, V. Martínez Gamero, Bertha Olivia Treviño Cavazos, Ezequiel Enrique Guerra Leal, Jesús Dante Mohamed Hamsho, Jesús |
| author_facet | González Cortés, Jesús Hernán Toledo Negrete, Juan José Butrón Valdez, K. Zapata Elizondo, V. Martínez Gamero, Bertha Olivia Treviño Cavazos, Ezequiel Enrique Guerra Leal, Jesús Dante Mohamed Hamsho, Jesús |
| author_sort | González Cortés, Jesús Hernán |
| collection | Repositorio Institucional |
| description | Purpose: To determine the effectiveness of three different combinations for the ‘‘loading phase’’ in the treatment of diabetic macular edema (DME), using bevacizumab (BVZ), triamcinolone (TCL) and subthreshold macular photocoagulation (SMPC). Methods: Experimental, longitudinal, prospective, comparative and blind. Patients were randomly assigned to three treatment branches: Group 1: BVZ + SMPC (12 eyes), Group 2: SMPC + BVZ + TCL (7 eyes), Group 3: BVZ + TCL (11 eyes). Treatment with BVZ and TCL was given every 4 weeks for 3 months, SMPC was applied once at the beginning of treatment. Initial and final measurements of best corrected visual acuity (BCVA), central macular thickness (CMT) and intraocular pressure (IOP) were tested.
Results: The improvement in BCVA and the reduction in CMT was statistically superior in group of BVZ + SMPCwhen compared to the other groups. There were no differences in IOP. Conclusions: Combined therapies in the ‘‘loading phase’’are a good option when treating DME. Although the group with BVZ + SMPC obtained the best results, further studies with longer followup and a higher number of participants to establish this combined therapy as the first treatment option are required. |
| format | Article |
| id | eprints-11641 |
| institution | UANL |
| language | English |
| publishDate | 2015 |
| publisher | UANL. Facultad de Medicina |
| record_format | eprints |
| spelling | eprints-116412021-08-04T16:28:27Z http://eprints.uanl.mx/11641/ Combined therapy in diabetic macular edema González Cortés, Jesús Hernán Toledo Negrete, Juan José Butrón Valdez, K. Zapata Elizondo, V. Martínez Gamero, Bertha Olivia Treviño Cavazos, Ezequiel Enrique Guerra Leal, Jesús Dante Mohamed Hamsho, Jesús RM Terapéutica, Farmacología Purpose: To determine the effectiveness of three different combinations for the ‘‘loading phase’’ in the treatment of diabetic macular edema (DME), using bevacizumab (BVZ), triamcinolone (TCL) and subthreshold macular photocoagulation (SMPC). Methods: Experimental, longitudinal, prospective, comparative and blind. Patients were randomly assigned to three treatment branches: Group 1: BVZ + SMPC (12 eyes), Group 2: SMPC + BVZ + TCL (7 eyes), Group 3: BVZ + TCL (11 eyes). Treatment with BVZ and TCL was given every 4 weeks for 3 months, SMPC was applied once at the beginning of treatment. Initial and final measurements of best corrected visual acuity (BCVA), central macular thickness (CMT) and intraocular pressure (IOP) were tested. Results: The improvement in BCVA and the reduction in CMT was statistically superior in group of BVZ + SMPCwhen compared to the other groups. There were no differences in IOP. Conclusions: Combined therapies in the ‘‘loading phase’’are a good option when treating DME. Although the group with BVZ + SMPC obtained the best results, further studies with longer followup and a higher number of participants to establish this combined therapy as the first treatment option are required. UANL. Facultad de Medicina 2015 Article PeerReviewed text en cc_by_nc http://eprints.uanl.mx/11641/1/S1665579615000459_S300_en.pdf http://eprints.uanl.mx/11641/1.haspreviewThumbnailVersion/S1665579615000459_S300_en.pdf González Cortés, Jesús Hernán y Toledo Negrete, Juan José y Butrón Valdez, K. y Zapata Elizondo, V. y Martínez Gamero, Bertha Olivia y Treviño Cavazos, Ezequiel Enrique y Guerra Leal, Jesús Dante y Mohamed Hamsho, Jesús (2015) Combined therapy in diabetic macular edema. Medicina universitaria, 17 (68). pp. 153-157. ISSN 1665-5796 |
| spellingShingle | RM Terapéutica, Farmacología González Cortés, Jesús Hernán Toledo Negrete, Juan José Butrón Valdez, K. Zapata Elizondo, V. Martínez Gamero, Bertha Olivia Treviño Cavazos, Ezequiel Enrique Guerra Leal, Jesús Dante Mohamed Hamsho, Jesús Combined therapy in diabetic macular edema |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Combined therapy in diabetic macular edema |
| title_full | Combined therapy in diabetic macular edema |
| title_fullStr | Combined therapy in diabetic macular edema |
| title_full_unstemmed | Combined therapy in diabetic macular edema |
| title_short | Combined therapy in diabetic macular edema |
| title_sort | combined therapy in diabetic macular edema |
| topic | RM Terapéutica, Farmacología |
| url | http://eprints.uanl.mx/11641/1/S1665579615000459_S300_en.pdf |
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