Search Results - CHHP~

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    Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1 by Shuyuan Chen, Raúl A., Bastarrachea, Raúl A., Voruganti, Venkata Saroja, Frost, Patrice A., Nava González, Edna Judith, Arriaga Cazarez, Jixji Chen, Huang, Pintong, DeFronzo, Ralph A., Comuzzie, Anthony G., Garyburn, Paul A.

    Published 2014
    “…This paper proposes a novel approach in which non-viral gene therapy is targeted to pancreatic islets using ultrasound targeted microbubble destruction (UTMD) in a non-human primate model (NHP), the baboon. Treated baboons received a gene cocktail comprised of cyclinD2, CDK, and GLP1, which in rats results in robust and durable islet regeneration with normalization of blood glucose, insulin, and C-peptide levels. …”
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