Resultados de búsqueda - ((miguel OR ligue) OR ((migne OR (emile OR (male OR mal))) OR (mine OR life))) 1~

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    A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers por León Cachón, Rafael B. R., Ascacio Martínez, Jorge Ángel Isidro, Gamino Peña, María E., Cerda Flores, Ricardo Martín, Meester, Irene, Gallardo Blanco, Hugo Leonid, Gómez Silva, Magdalena, Piñeyro Garza, Everardo, Barrera Saldaña, Hugo Alberto

    Publicado 2016
    “…Background: The genetic variation underlying atorvastatin (ATV) pharmacokinetics was evaluated in a Mexican population. Aims of this study were: 1) to reveal the frequency of 87 polymorphisms in 36 genes related to drug metabolism in healthy Mexican volunteers, 2) to evaluate the impact of these polymorphisms on ATV pharmacokinetics, 3) to classify the ATV metabolic phenotypes of healthy volunteers, and 4) to investigate a possible association between genotypes and metabolizer phenotypes. …”
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