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Stereochemical preference toward oncotarget: Design, synthesis and <i>in vitro</i> anticancer evaluation of diastereomeric β-lactams
Publicado 2017“…A cis-β-lactam [(±)-Cis3-amino-1-phenyl-4-(p-tolyl) azetidin-2-one, 6C] was found to be more active (in vitro) than the marketed natural drug colchicine against SiHa and B16F10 (six times higher potency) cell lines. …”
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Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells
Publicado 2016“…The luciferase reporter assay was used to evaluate targeting of SIAH1, PTP4A1 and PRKCA genes by miR-944. SIAH1 protein levels were measured by Western blot. …”
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Interacción del complejo WT1-Par4 con el promotor P1 DE Bcl-2 en la línea celular MCF7 en presencia y ausencia de estímulo estrogénico
Publicado 2006“…In this work we propose to determinate the existence of a WT1-Par4 complex, its ability to bind the Bcl-2 promoter, and a possible relation with RE in the MCF7 cell line model, to aim it we used the cell culture, immunoprecipitation, Pull down and Western blot techniques. …”
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Interacción del complejo WT1-Par4 con el promotor P1 DE Bcl-2 en la línea celular MCF7 en presencia y ausencia de estímulo estrogénico
Publicado 2006“…In this work we propose to determinate the existence of a WT1-Par4 complex, its ability to bind the Bcl-2 promoter, and a possible relation with RE in the MCF7 cell line model, to aim it we used the cell culture, immunoprecipitation, Pull down and Western blot techniques. …”
Enlace del recurso
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Fármacos epigenéticos con efecto en la actividad promotora del gen rb1 en células hepáticas humanas
Publicado 2019“…Previously it was observed that the expression of RB1 was increased in the presence of the epigenetic drugs isotretinoin and thalidomide in the HepG2 cell line. …”
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Fármacos epigenéticos con efecto en la actividad promotora del gen rb1 en células hepáticas humanas
Publicado 2019“…Previously it was observed that the expression of RB1 was increased in the presence of the epigenetic drugs isotretinoin and thalidomide in the HepG2 cell line. …”
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WT1 shRNA delivery using transferrin-conjugated PEG liposomes in an in vivo model of melanoma
Publicado 2016“…Formulations of transferrin (Tf)‑conjugated polyethylene glycol (PEG) liposomes loaded with short hairpin RNA (shRNA) against WT1 (Lip + RNAi + Tf), PEG liposomes loaded with shRNA against WT1 (Lip + RNAi), Tf‑conjugated PEG liposomes loaded with pEGFP‑N3 (Lip + GFP + Tf) and saline solution as negative control (untreated) were administered systemically to C57BL/6 mice implanted subcutaneously with a melanoma cell line. …”
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Metabolomic and biodirected phytochemical study of Hechtia glomerata, evaluation of its antibacterial and cytotoxic activity, and determination of the mechanism of action of one ac...
Publicado 2020“…For these reasons it was decided to focus on the CHCl3/MeOH extract, which presented activity against PC3 and was slightly active against MCF7 cell lines. A bioassay-guided directed study was also conducted on this extract showing fractions 3 and 4 as the most active ones. …”
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Metabolomic and biodirected phytochemical study of Hechtia glomerata, evaluation of its antibacterial and cytotoxic activity, and determination of the mechanism of action of one ac...
Publicado 2020“…For these reasons it was decided to focus on the CHCl3/MeOH extract, which presented activity against PC3 and was slightly active against MCF7 cell lines. A bioassay-guided directed study was also conducted on this extract showing fractions 3 and 4 as the most active ones. …”
Enlace del recurso
Tesis