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    A cellularized biphasic implant based on a bioactive silk fibroin promotes integration and tissue organization during osteochondral defect repair in a porcine model by Pérez Silos, Vanessa, Moncada Saucedo, Nidia Karina, Peña Martínez, Víctor Manuel, Lara Arias, Jorge, Marino Martínez, Iván Alberto, Camacho Morales, Alberto, Romero Díaz, Víktor J., Lara Banda, María del Refugio, García Ruíz, Alejandro, Soto Domínguez, Adolfo, Rodríguez Rocha, Humberto, López Serna, Norberto, Tuan, Rocky S., Lin, Hang, Fuentes Mera, Lizeth

    Published 2019
    “…In cartilage tissue engineering, biphasic scaffolds (BSs) have been designed not only to influence the recapitulation of the osteochondral architecture but also to take advantage of the healing ability of bone, promoting the implant’s integration with the surrounding tissue and then bone restoration and cartilage regeneration. This study reports the development and characterization of a BS based on the assembly of a cartilage phase constituted by fibroin biofunctionalyzed with a bovine cartilage matrix, cellularized with differentiated autologous pre-chondrocytes and well attached to a bone phase (decellularized bovine bone) to promote cartilage regeneration in a model of joint damage in pigs. …”
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