Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp
Aquaculture is part of the solution for meeting the growing world demand for food, mainly as an animalprotein source. However, current yields are insufficient for aquaculture to play this crucial role. Growth-rateenhancement is one of the approaches that have been exploited in this regard. Also, los...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Facultad de Ciencias Biologicas
2017
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| Online Access: | https://nutricionacuicola.uanl.mx/index.php/acu/article/view/24 |
| _version_ | 1824324437717024768 |
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| author | Martínez, Rebeca Carpio, Yamila Hernández, Liz Morales, Antonio Herrera, Fidel Morales, Reynold Estrada, Mario Pablo |
| author_facet | Martínez, Rebeca Carpio, Yamila Hernández, Liz Morales, Antonio Herrera, Fidel Morales, Reynold Estrada, Mario Pablo |
| author_sort | Martínez, Rebeca |
| collection | Artículos de Revistas UANL |
| description | Aquaculture is part of the solution for meeting the growing world demand for food, mainly as an animalprotein source. However, current yields are insufficient for aquaculture to play this crucial role. Growth-rateenhancement is one of the approaches that have been exploited in this regard. Also, losses caused by bacteria,viruses and parasites remain a significant problem. It has been demonstrated that growth stimulants contributenot only to growth enhancement but also to fish health improvement. Growth Hormone Releasing Peptide-6(GHRP-6) is one of the earliest-developed, synthetic, peptidyl growth hormone secretagogue receptoragonists. These compounds mimic the effect of the endogenous ligand, ghrelin. This peptide has shown itsbenefits for both growth enhancement and immune system stimulation in fish and crustaceans. In the presentstudy, we demonstrate that intraperitoneal administration of GHRP-6 induces liver insulin growth factor-Imessenger RNA, and increases growth hormone levels in juvenile tilapia (Oreochromis sp.), in a time-courseexperiment. In addition, administration of GHRP-6 in formulated feed to tilapia larvae was assessed. Growthand immune parameters such as lectin titers and intestinal intraepithelial lymphocyte numbers were increasedin treated larvae. We also evaluated the effect of GHRP-6 injection over feed intake in shrimp and its effectson shrimp growth when the peptide was administrated by successive immersion baths. GHRP-6 increasedfeed intake, body weight and size, the number of rostral spines and gill branches, protein concentration andhaemocyte number in treated shrimps. |
| first_indexed | 2025-02-05T19:05:31Z |
| format | Article |
| id | nutrucionacuicola-article-24 |
| institution | UANL |
| language | spa |
| last_indexed | 2025-02-05T19:05:31Z |
| physical | Avances en Nutrición Acuicola; 2017: Investigación y Desarrollo en Nutrición Acuícola 2017 |
| publishDate | 2017 |
| publisher | Facultad de Ciencias Biologicas |
| record_format | ojs |
| spelling | nutrucionacuicola-article-242020-07-29T23:23:47Z Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp Martínez, Rebeca Carpio, Yamila Hernández, Liz Morales, Antonio Herrera, Fidel Morales, Reynold Estrada, Mario Pablo Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state Aquaculture is part of the solution for meeting the growing world demand for food, mainly as an animalprotein source. However, current yields are insufficient for aquaculture to play this crucial role. Growth-rateenhancement is one of the approaches that have been exploited in this regard. Also, losses caused by bacteria,viruses and parasites remain a significant problem. It has been demonstrated that growth stimulants contributenot only to growth enhancement but also to fish health improvement. Growth Hormone Releasing Peptide-6(GHRP-6) is one of the earliest-developed, synthetic, peptidyl growth hormone secretagogue receptoragonists. These compounds mimic the effect of the endogenous ligand, ghrelin. This peptide has shown itsbenefits for both growth enhancement and immune system stimulation in fish and crustaceans. In the presentstudy, we demonstrate that intraperitoneal administration of GHRP-6 induces liver insulin growth factor-Imessenger RNA, and increases growth hormone levels in juvenile tilapia (Oreochromis sp.), in a time-courseexperiment. In addition, administration of GHRP-6 in formulated feed to tilapia larvae was assessed. Growthand immune parameters such as lectin titers and intestinal intraepithelial lymphocyte numbers were increasedin treated larvae. We also evaluated the effect of GHRP-6 injection over feed intake in shrimp and its effectson shrimp growth when the peptide was administrated by successive immersion baths. GHRP-6 increasedfeed intake, body weight and size, the number of rostral spines and gill branches, protein concentration andhaemocyte number in treated shrimps. Aquaculture is part of the solution for meeting the growing world demand for food, mainly as an animalprotein source. However, current yields are insufficient for aquaculture to play this crucial role. Growth-rateenhancement is one of the approaches that have been exploited in this regard. Also, losses caused by bacteria,viruses and parasites remain a significant problem. It has been demonstrated that growth stimulants contributenot only to growth enhancement but also to fish health improvement. Growth Hormone Releasing Peptide-6(GHRP-6) is one of the earliest-developed, synthetic, peptidyl growth hormone secretagogue receptoragonists. These compounds mimic the effect of the endogenous ligand, ghrelin. This peptide has shown itsbenefits for both growth enhancement and immune system stimulation in fish and crustaceans. In the presentstudy, we demonstrate that intraperitoneal administration of GHRP-6 induces liver insulin growth factor-Imessenger RNA, and increases growth hormone levels in juvenile tilapia (Oreochromis sp.), in a time-courseexperiment. In addition, administration of GHRP-6 in formulated feed to tilapia larvae was assessed. Growthand immune parameters such as lectin titers and intestinal intraepithelial lymphocyte numbers were increasedin treated larvae. We also evaluated the effect of GHRP-6 injection over feed intake in shrimp and its effectson shrimp growth when the peptide was administrated by successive immersion baths. GHRP-6 increasedfeed intake, body weight and size, the number of rostral spines and gill branches, protein concentration andhaemocyte number in treated shrimps. Facultad de Ciencias Biologicas 2017-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artículo revisado por pares application/pdf https://nutricionacuicola.uanl.mx/index.php/acu/article/view/24 Avances en Nutrición Acuicola; 2017: Investigación y Desarrollo en Nutrición Acuícola 2017 spa https://nutricionacuicola.uanl.mx/index.php/acu/article/view/24/24 Derechos de autor 2019 Rebeca Martínez, Yamila Carpio, Liz Hernández, Antonio Morales, Fidel Herrera, Reynold Morales, Mario Pablo Estrada |
| spellingShingle | Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state Martínez, Rebeca Carpio, Yamila Hernández, Liz Morales, Antonio Herrera, Fidel Morales, Reynold Estrada, Mario Pablo Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/article.gif |
| title | Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp |
| title_alt | Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp |
| title_full | Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp |
| title_fullStr | Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp |
| title_full_unstemmed | Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp |
| title_short | Synthetic Growth Hormone Secretagogue GHRP-6 Exhibits Enhanced Growth Activity and Immune System Stimulation in Teleost Fish and Shrimp |
| title_sort | synthetic growth hormone secretagogue ghrp 6 exhibits enhanced growth activity and immune system stimulation in teleost fish and shrimp |
| topic | Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state |
| topic_facet | Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state Growth Hormone Secretagogues Peptides Larvae growth Innate Immune state |
| url | https://nutricionacuicola.uanl.mx/index.php/acu/article/view/24 |
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