Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia.
Deletions of the long arm of chromosome 9, del(9)(q22), are rare aberrations specifically found in acute myeloid leukemia (AML). Yamamoto et al, 1999, reported the first case of acute promyelocytic leukemia (APL) with a terminal 9q deletion as a sole abnormality. Here we describe the second case wi...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Masson Doyma México, S.A
2009
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| Acceso en línea: | http://eprints.uanl.mx/8312/1/Cytogenetic%20analysis%20and%20FISH.pdf |
| _version_ | 1824370684245049344 |
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| author | Vásquez Palacio, Gonzalo Botero, Olga Sierra, Margarita Tubo, Taknida Quintero Rivera, Fabiola |
| author_facet | Vásquez Palacio, Gonzalo Botero, Olga Sierra, Margarita Tubo, Taknida Quintero Rivera, Fabiola |
| author_sort | Vásquez Palacio, Gonzalo |
| collection | Repositorio Institucional |
| description | Deletions of the long arm of chromosome 9, del(9)(q22), are rare aberrations specifically found in acute myeloid leukemia (AML). Yamamoto et al, 1999, reported the first case of acute promyelocytic leukemia (APL) with a terminal 9q deletion as a sole
abnormality. Here we describe the second case with the same aberration, the patient, an eleven-years-old girl with APL. Chromosomal analysis by the Giemsa R-banding technique and FISH using BCR/ABL and PML/RARA probe on short-term cell cultures from bone marrow was performed. A deletion of a 9 chromosome, del(9)(q22) was detected. Deletions of 9q have been described in about 3% to 4% of the AML patients, especially in M1 and M2 myeloid leukemia. Sole 9q terminal deletions, are less common than interstitial ones and involve q21~q22 band predominantly. A recent study suggests that 9q deletion, even in the absence of t(15;17), shows a relatively good prognosis. However, our patient died during the treatment. |
| format | Article |
| id | eprints-8312 |
| institution | UANL |
| language | English |
| publishDate | 2009 |
| publisher | Masson Doyma México, S.A |
| record_format | eprints |
| spelling | eprints-83122015-12-08T02:12:29Z http://eprints.uanl.mx/8312/ Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. Vásquez Palacio, Gonzalo Botero, Olga Sierra, Margarita Tubo, Taknida Quintero Rivera, Fabiola Deletions of the long arm of chromosome 9, del(9)(q22), are rare aberrations specifically found in acute myeloid leukemia (AML). Yamamoto et al, 1999, reported the first case of acute promyelocytic leukemia (APL) with a terminal 9q deletion as a sole abnormality. Here we describe the second case with the same aberration, the patient, an eleven-years-old girl with APL. Chromosomal analysis by the Giemsa R-banding technique and FISH using BCR/ABL and PML/RARA probe on short-term cell cultures from bone marrow was performed. A deletion of a 9 chromosome, del(9)(q22) was detected. Deletions of 9q have been described in about 3% to 4% of the AML patients, especially in M1 and M2 myeloid leukemia. Sole 9q terminal deletions, are less common than interstitial ones and involve q21~q22 band predominantly. A recent study suggests that 9q deletion, even in the absence of t(15;17), shows a relatively good prognosis. However, our patient died during the treatment. Masson Doyma México, S.A 2009 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/8312/1/Cytogenetic%20analysis%20and%20FISH.pdf http://eprints.uanl.mx/8312/1.haspreviewThumbnailVersion/Cytogenetic%20analysis%20and%20FISH.pdf Vásquez Palacio, Gonzalo y Botero, Olga y Sierra, Margarita y Tubo, Taknida y Quintero Rivera, Fabiola (2009) Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. Medicina Universitaria, 11 (44). pp. 193-197. ISSN 1665-5796 (Entregado) |
| spellingShingle | Vásquez Palacio, Gonzalo Botero, Olga Sierra, Margarita Tubo, Taknida Quintero Rivera, Fabiola Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. |
| title_full | Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. |
| title_fullStr | Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. |
| title_full_unstemmed | Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. |
| title_short | Cytogenetic analysis and FISH of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia. |
| title_sort | cytogenetic analysis and fish of terminal deletion of the long arm of chromosome 9 in a patient with acute promyelocytic leukemia |
| url | http://eprints.uanl.mx/8312/1/Cytogenetic%20analysis%20and%20FISH.pdf |
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