Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8? T-cells and directs migration of CD4? and CD8? lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2009
|
| Subjects: | |
| Online Access: | http://eprints.uanl.mx/5430/1/00b4952ab76503b41e000000.pdf |
| _version_ | 1824369759869730816 |
|---|---|
| author | Zavala Flores, Laura Mireya Villatoro Hernández, Julio Gámez Escobedo, Idalia Analí Franco Molina, Moisés Armides Rangel Colmenero, Blanca Rocío Villanueva Olivo, Arnulfo Gutiérrez Puente, Yolanda Montes de Oca Luna, Roberto Valdés Flores, Jesús Saucedo Cárdenas, Odila |
| author_facet | Zavala Flores, Laura Mireya Villatoro Hernández, Julio Gámez Escobedo, Idalia Analí Franco Molina, Moisés Armides Rangel Colmenero, Blanca Rocío Villanueva Olivo, Arnulfo Gutiérrez Puente, Yolanda Montes de Oca Luna, Roberto Valdés Flores, Jesús Saucedo Cárdenas, Odila |
| author_sort | Zavala Flores, Laura Mireya |
| collection | Repositorio Institucional |
| description | Lymphotactin-XCL1 is a chemokine
produced mainly by activated CD8? T-cells and
directs migration of CD4? and CD8? lymphocytes
and natural killer (NK) cells. We expressed human
lymphotactin (LTN) by the lactic-acid bacterium
Lactococcus lactis. Biological activity of LTN was
confirmed by chemo-attraction of human T-cells by
chemotaxis demonstrating, for the first time, how this
chemokine secreted by a food-grade prokaryote
retains biological activity and chemoattracts T lymphocytes.
This strain thus represents a feasible
well-tolerated vector to deliver active LTN at a
mucosal level. |
| format | Article |
| id | eprints-5430 |
| institution | UANL |
| language | English |
| publishDate | 2009 |
| record_format | eprints |
| spelling | eprints-54302022-03-27T13:41:17Z http://eprints.uanl.mx/5430/ Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis Zavala Flores, Laura Mireya Villatoro Hernández, Julio Gámez Escobedo, Idalia Analí Franco Molina, Moisés Armides Rangel Colmenero, Blanca Rocío Villanueva Olivo, Arnulfo Gutiérrez Puente, Yolanda Montes de Oca Luna, Roberto Valdés Flores, Jesús Saucedo Cárdenas, Odila GV Deportes y Recreación Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8? T-cells and directs migration of CD4? and CD8? lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for the first time, how this chemokine secreted by a food-grade prokaryote retains biological activity and chemoattracts T lymphocytes. This strain thus represents a feasible well-tolerated vector to deliver active LTN at a mucosal level. 2009 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/5430/1/00b4952ab76503b41e000000.pdf http://eprints.uanl.mx/5430/1.haspreviewThumbnailVersion/00b4952ab76503b41e000000.pdf Zavala Flores, Laura Mireya y Villatoro Hernández, Julio y Gámez Escobedo, Idalia Analí y Franco Molina, Moisés Armides y Rangel Colmenero, Blanca Rocío y Villanueva Olivo, Arnulfo y Gutiérrez Puente, Yolanda y Montes de Oca Luna, Roberto y Valdés Flores, Jesús y Saucedo Cárdenas, Odila (2009) Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis. Biotechnol lett, 31. pp. 215-220. |
| spellingShingle | GV Deportes y Recreación Zavala Flores, Laura Mireya Villatoro Hernández, Julio Gámez Escobedo, Idalia Analí Franco Molina, Moisés Armides Rangel Colmenero, Blanca Rocío Villanueva Olivo, Arnulfo Gutiérrez Puente, Yolanda Montes de Oca Luna, Roberto Valdés Flores, Jesús Saucedo Cárdenas, Odila Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Production of biologically active human lymphotactin
(XCL1) by Lactococcus lactis |
| title_full | Production of biologically active human lymphotactin
(XCL1) by Lactococcus lactis |
| title_fullStr | Production of biologically active human lymphotactin
(XCL1) by Lactococcus lactis |
| title_full_unstemmed | Production of biologically active human lymphotactin
(XCL1) by Lactococcus lactis |
| title_short | Production of biologically active human lymphotactin
(XCL1) by Lactococcus lactis |
| title_sort | production of biologically active human lymphotactin xcl1 by lactococcus lactis |
| topic | GV Deportes y Recreación |
| url | http://eprints.uanl.mx/5430/1/00b4952ab76503b41e000000.pdf |
| work_keys_str_mv | AT zavalafloreslauramireya productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT villatorohernandezjulio productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT gamezescobedoidaliaanali productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT francomolinamoisesarmides productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT rangelcolmeneroblancarocio productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT villanuevaolivoarnulfo productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT gutierrezpuenteyolanda productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT montesdeocalunaroberto productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT valdesfloresjesus productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis AT saucedocardenasodila productionofbiologicallyactivehumanlymphotactinxcl1bylactococcuslactis |