Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population

Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Cárdenas Estrada, Eloy, Oliveira, Lindomar Guimarães, Abad, Hernán Leonardo, Elayan, F., Khalifa, N., El-Husseini, Timour
Formato: Artículo
Lenguaje:inglés
Publicado: 2009
Materias:
Acceso en línea:http://eprints.uanl.mx/4440/1/2009-Celecoxib-V37-N06-DrECE.pdf
_version_ 1824369444216897536
author Cárdenas Estrada, Eloy
Oliveira, Lindomar Guimarães
Abad, Hernán Leonardo
Elayan, F.
Khalifa, N.
El-Husseini, Timour
author_facet Cárdenas Estrada, Eloy
Oliveira, Lindomar Guimarães
Abad, Hernán Leonardo
Elayan, F.
Khalifa, N.
El-Husseini, Timour
author_sort Cárdenas Estrada, Eloy
collection Repositorio Institucional
description Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Patients received either celecoxib (400 mg loading dose followed by 200 mg twice daily) or standard doses of non-selective NSAIDs. The primary endpoint was a change in the patient’s assessment of ankle pain on a 0 mm (no pain) – 100 mm (worst possible pain) visual analogue scale (VAS) at day 3 compared with baseline. From a baseline of 73 mm, mean VAS pain scores decreased to 29 and 32 mm in the celecoxib and non-selective NSAID groups, respectively. The lower limit of the 95% confidence interval for the treatment difference with regard to change from baseline was greater than the preestablished non-inferiority margin of –10 mm. Using an initial loading dose, celecoxib was at least as efficacious as non-selective NSAIDs in treating acute pain due to ankle sprain
format Article
id eprints-4440
institution UANL
language English
publishDate 2009
record_format eprints
spelling eprints-44402020-04-27T17:51:36Z http://eprints.uanl.mx/4440/ Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population Cárdenas Estrada, Eloy Oliveira, Lindomar Guimarães Abad, Hernán Leonardo Elayan, F. Khalifa, N. El-Husseini, Timour RC Medicina Interna, Psiquiatría, Neurología RM Terapéutica, Farmacología Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Patients received either celecoxib (400 mg loading dose followed by 200 mg twice daily) or standard doses of non-selective NSAIDs. The primary endpoint was a change in the patient’s assessment of ankle pain on a 0 mm (no pain) – 100 mm (worst possible pain) visual analogue scale (VAS) at day 3 compared with baseline. From a baseline of 73 mm, mean VAS pain scores decreased to 29 and 32 mm in the celecoxib and non-selective NSAID groups, respectively. The lower limit of the 95% confidence interval for the treatment difference with regard to change from baseline was greater than the preestablished non-inferiority margin of –10 mm. Using an initial loading dose, celecoxib was at least as efficacious as non-selective NSAIDs in treating acute pain due to ankle sprain 2009 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/4440/1/2009-Celecoxib-V37-N06-DrECE.pdf http://eprints.uanl.mx/4440/1.haspreviewThumbnailVersion/2009-Celecoxib-V37-N06-DrECE.pdf Cárdenas Estrada, Eloy y Oliveira, Lindomar Guimarães y Abad, Hernán Leonardo y Elayan, F. y Khalifa, N. y El-Husseini, Timour (2009) Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population. The Journal of International Medical Research, 37 (6). pp. 1937-1951. ISSN 1473-2300 http://imr.sagepub.com/content/37/6/1937.full.pdf+html
spellingShingle RC Medicina Interna, Psiquiatría, Neurología
RM Terapéutica, Farmacología
Cárdenas Estrada, Eloy
Oliveira, Lindomar Guimarães
Abad, Hernán Leonardo
Elayan, F.
Khalifa, N.
El-Husseini, Timour
Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
title_full Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
title_fullStr Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
title_full_unstemmed Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
title_short Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
title_sort efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
topic RC Medicina Interna, Psiquiatría, Neurología
RM Terapéutica, Farmacología
url http://eprints.uanl.mx/4440/1/2009-Celecoxib-V37-N06-DrECE.pdf
work_keys_str_mv AT cardenasestradaeloy efficacyandsafetyofcelecoxibinthetreatmentofacutepainduetoanklespraininalatinamericanandmiddleeasternpopulation
AT oliveiralindomarguimaraes efficacyandsafetyofcelecoxibinthetreatmentofacutepainduetoanklespraininalatinamericanandmiddleeasternpopulation
AT abadhernanleonardo efficacyandsafetyofcelecoxibinthetreatmentofacutepainduetoanklespraininalatinamericanandmiddleeasternpopulation
AT elayanf efficacyandsafetyofcelecoxibinthetreatmentofacutepainduetoanklespraininalatinamericanandmiddleeasternpopulation
AT khalifan efficacyandsafetyofcelecoxibinthetreatmentofacutepainduetoanklespraininalatinamericanandmiddleeasternpopulation
AT elhusseinitimour efficacyandsafetyofcelecoxibinthetreatmentofacutepainduetoanklespraininalatinamericanandmiddleeasternpopulation