Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population
Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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2009
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| Online Access: | http://eprints.uanl.mx/4440/1/2009-Celecoxib-V37-N06-DrECE.pdf |
| _version_ | 1824369444216897536 |
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| author | Cárdenas Estrada, Eloy Oliveira, Lindomar Guimarães Abad, Hernán Leonardo Elayan, F. Khalifa, N. El-Husseini, Timour |
| author_facet | Cárdenas Estrada, Eloy Oliveira, Lindomar Guimarães Abad, Hernán Leonardo Elayan, F. Khalifa, N. El-Husseini, Timour |
| author_sort | Cárdenas Estrada, Eloy |
| collection | Repositorio Institucional |
| description | Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Patients received either celecoxib (400 mg loading dose followed by 200 mg twice daily) or standard doses of non-selective NSAIDs. The primary endpoint was a change in the patient’s assessment of ankle pain on a 0 mm (no pain) – 100 mm (worst possible pain) visual analogue scale (VAS) at day 3 compared with baseline. From a baseline of 73 mm, mean VAS pain scores decreased to 29 and 32 mm in the celecoxib and non-selective NSAID groups, respectively. The lower limit of the 95% confidence interval for the treatment difference with regard to change from baseline was greater than the preestablished non-inferiority margin of –10 mm. Using an initial loading dose, celecoxib was at least as efficacious as non-selective NSAIDs in treating acute pain due to ankle sprain |
| format | Article |
| id | eprints-4440 |
| institution | UANL |
| language | English |
| publishDate | 2009 |
| record_format | eprints |
| spelling | eprints-44402020-04-27T17:51:36Z http://eprints.uanl.mx/4440/ Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population Cárdenas Estrada, Eloy Oliveira, Lindomar Guimarães Abad, Hernán Leonardo Elayan, F. Khalifa, N. El-Husseini, Timour RC Medicina Interna, Psiquiatría, Neurología RM Terapéutica, Farmacología Ankle sprains are common acute softtissue injuries. This 7-day open-label, multicentre, randomized study compared the efficacy and safety of celecoxib with non-selective non-steroidal antiinflammatory drugs (NSAIDs) in treating acute ankle sprain with moderate-tosevere ankle pain in 278 patients. Patients received either celecoxib (400 mg loading dose followed by 200 mg twice daily) or standard doses of non-selective NSAIDs. The primary endpoint was a change in the patient’s assessment of ankle pain on a 0 mm (no pain) – 100 mm (worst possible pain) visual analogue scale (VAS) at day 3 compared with baseline. From a baseline of 73 mm, mean VAS pain scores decreased to 29 and 32 mm in the celecoxib and non-selective NSAID groups, respectively. The lower limit of the 95% confidence interval for the treatment difference with regard to change from baseline was greater than the preestablished non-inferiority margin of –10 mm. Using an initial loading dose, celecoxib was at least as efficacious as non-selective NSAIDs in treating acute pain due to ankle sprain 2009 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/4440/1/2009-Celecoxib-V37-N06-DrECE.pdf http://eprints.uanl.mx/4440/1.haspreviewThumbnailVersion/2009-Celecoxib-V37-N06-DrECE.pdf Cárdenas Estrada, Eloy y Oliveira, Lindomar Guimarães y Abad, Hernán Leonardo y Elayan, F. y Khalifa, N. y El-Husseini, Timour (2009) Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population. The Journal of International Medical Research, 37 (6). pp. 1937-1951. ISSN 1473-2300 http://imr.sagepub.com/content/37/6/1937.full.pdf+html |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología RM Terapéutica, Farmacología Cárdenas Estrada, Eloy Oliveira, Lindomar Guimarães Abad, Hernán Leonardo Elayan, F. Khalifa, N. El-Husseini, Timour Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population |
| title_full | Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population |
| title_fullStr | Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population |
| title_full_unstemmed | Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population |
| title_short | Efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population |
| title_sort | efficacy and safety of celecoxib in the treatment of acute pain due to ankle sprain in a latin american and middle eastern population |
| topic | RC Medicina Interna, Psiquiatría, Neurología RM Terapéutica, Farmacología |
| url | http://eprints.uanl.mx/4440/1/2009-Celecoxib-V37-N06-DrECE.pdf |
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