Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a fea...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Microbiologia
2022
|
| Online Access: | http://eprints.uanl.mx/30135/7/30135.pdf |
| _version_ | 1838551028266434560 |
|---|---|
| author | Alanís Ríos, Sergio A. González, Gloria M. Andrade, Angel Becerril García, Miguel A. Bonifaz, Alexandro Robledo Leal, Efrén Ricardo Montoya, Alexandra M. Treviño Rangel, Rogelio de Jesús |
| author_facet | Alanís Ríos, Sergio A. González, Gloria M. Andrade, Angel Becerril García, Miguel A. Bonifaz, Alexandro Robledo Leal, Efrén Ricardo Montoya, Alexandra M. Treviño Rangel, Rogelio de Jesús |
| author_sort | Alanís Ríos, Sergio A. |
| collection | Repositorio Institucional |
| description | Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of C. auris. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indiferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating C. auris infections. |
| format | Article |
| id | eprints-30135 |
| institution | UANL |
| language | English |
| publishDate | 2022 |
| publisher | Sociedade Brasileira de Microbiologia |
| record_format | eprints |
| spelling | eprints-301352025-07-18T17:24:23Z http://eprints.uanl.mx/30135/ Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris Alanís Ríos, Sergio A. González, Gloria M. Andrade, Angel Becerril García, Miguel A. Bonifaz, Alexandro Robledo Leal, Efrén Ricardo Montoya, Alexandra M. Treviño Rangel, Rogelio de Jesús Candida auris is an emerging global public health threat. It is an opportunistic yeast that usually affects critically ill patients in healthcare settings and is characterized by reduced susceptibility to multiple antifungal classes. Combination therapy with antifungals and repurposed drugs is a feasible alternative to overcome this problem. The aim of this study was to examine the in vitro interactions and potential synergy of micafungin (MFG) and voriconazole (VRC) plus the antidepressant sertraline (SRT) against clinical isolates of C. auris. Conventional antifungal testing was first performed with the three drugs according to the CLSI methodology. Drug interactions were determined by the checkerboard microdilution assay using the fractional inhibitory concentration (FIC) index. Synergistic interactions were noted with the combination of MFG and SRT plus VRC with FIC values of 0.37 to 0.49 for some strains. Indiferent interactions were observed when MFG was combined with SRT with just one exception (FIC 0.53). No antagonism was observed for any combination. The combination of VRC with MCF or SRT may be relevant for treating C. auris infections. Sociedade Brasileira de Microbiologia 2022-08-22 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/30135/7/30135.pdf http://eprints.uanl.mx/30135/7.haspreviewThumbnailVersion/30135.pdf Alanís Ríos, Sergio A. y González, Gloria M. y Andrade, Angel y Becerril García, Miguel A. y Bonifaz, Alexandro y Robledo Leal, Efrén Ricardo y Montoya, Alexandra M. y Treviño Rangel, Rogelio de Jesús (2022) Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris. Brazilian Journal of Microbiology, 53 (4). pp. 2003-2008. ISSN 1517-8382 doi:10.1007/s42770-022-00817-y |
| spellingShingle | Alanís Ríos, Sergio A. González, Gloria M. Andrade, Angel Becerril García, Miguel A. Bonifaz, Alexandro Robledo Leal, Efrén Ricardo Montoya, Alexandra M. Treviño Rangel, Rogelio de Jesús Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris |
| title_full | Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris |
| title_fullStr | Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris |
| title_full_unstemmed | Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris |
| title_short | Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris |
| title_sort | evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against candida auris |
| url | http://eprints.uanl.mx/30135/7/30135.pdf |
| work_keys_str_mv | AT alanisriossergioa evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris AT gonzalezgloriam evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris AT andradeangel evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris AT becerrilgarciamiguela evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris AT bonifazalexandro evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris AT robledolealefrenricardo evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris AT montoyaalexandram evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris AT trevinorangelrogeliodejesus evaluationofthesynergisticantifungalactivityofmicafunginandvoriconazoleplussertralineagainstcandidaauris |