Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study

Background Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS. Methods This was an observational study. A to...

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Autores principales: Bello Chavolla, Omar Yaxmehen, Cura Esquivel, Idalia, Perales Quintana, Marlene Marisol, Torres González, Liliana, Guzmán Avilán, Katia, Muñoz Espinosa, Linda, Cordero Pérez, Paula
Formato: Artículo
Lenguaje:inglés
Publicado: PLOS ONE 2023
Acceso en línea:http://eprints.uanl.mx/30087/7/30087.pdf
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author Bello Chavolla, Omar Yaxmehen
Cura Esquivel, Idalia
Perales Quintana, Marlene Marisol
Torres González, Liliana
Guzmán Avilán, Katia
Muñoz Espinosa, Linda
Cordero Pérez, Paula
author_facet Bello Chavolla, Omar Yaxmehen
Cura Esquivel, Idalia
Perales Quintana, Marlene Marisol
Torres González, Liliana
Guzmán Avilán, Katia
Muñoz Espinosa, Linda
Cordero Pérez, Paula
author_sort Bello Chavolla, Omar Yaxmehen
collection Repositorio Institucional
description Background Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS. Methods This was an observational study. A total of 107 children and adolescents aged 6–18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/ obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios. Results Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDLC ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled. Conclusion Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity.
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spelling eprints-300872025-06-24T15:01:50Z http://eprints.uanl.mx/30087/ Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study Bello Chavolla, Omar Yaxmehen Cura Esquivel, Idalia Perales Quintana, Marlene Marisol Torres González, Liliana Guzmán Avilán, Katia Muñoz Espinosa, Linda Cordero Pérez, Paula Background Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS. Methods This was an observational study. A total of 107 children and adolescents aged 6–18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/ obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios. Results Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDLC ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled. Conclusion Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity. PLOS ONE 2023-03-15 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/30087/7/30087.pdf http://eprints.uanl.mx/30087/7.haspreviewThumbnailVersion/30087.pdf Bello Chavolla, Omar Yaxmehen y Cura Esquivel, Idalia y Perales Quintana, Marlene Marisol y Torres González, Liliana y Guzmán Avilán, Katia y Muñoz Espinosa, Linda y Cordero Pérez, Paula (2023) Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study. PLOS ONE, 18 (3). e0281381. ISSN 1932-6203 doi:10.1371/journal.pone.0281381
spellingShingle Bello Chavolla, Omar Yaxmehen
Cura Esquivel, Idalia
Perales Quintana, Marlene Marisol
Torres González, Liliana
Guzmán Avilán, Katia
Muñoz Espinosa, Linda
Cordero Pérez, Paula
Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study
title_full Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study
title_fullStr Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study
title_full_unstemmed Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study
title_short Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: a cross-sectional study
title_sort metabolic inflammatory and adipokine differences on overweight obese children with and without metabolic syndrome a cross sectional study
url http://eprints.uanl.mx/30087/7/30087.pdf
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