Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis
Objective: The objective of the study was to determine the added value of synovial fluid (SF) glucose levels and other biochemical parameters as possible biomarkers of bacterial septic arthritis (SA). Materials and methods: We prospectively examined adult patients with SA. As a control group, adults...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
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Academia Mexicana de Cirugía
2022
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/30021/1/1368.pdf |
| _version_ | 1838551027127681024 |
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| author | González Chapa, Jorge A. Peña Martínez, Víctor Manuel González, Gloria M. Vílchez Cavazos, José Félix Treviño Rangel, Rogelio J. Salinas Carmona, Mario César Rosas Taraco, Adrian G. |
| author_facet | González Chapa, Jorge A. Peña Martínez, Víctor Manuel González, Gloria M. Vílchez Cavazos, José Félix Treviño Rangel, Rogelio J. Salinas Carmona, Mario César Rosas Taraco, Adrian G. |
| author_sort | González Chapa, Jorge A. |
| collection | Repositorio Institucional |
| description | Objective: The objective of the study was to determine the added value of synovial fluid (SF) glucose levels and other biochemical parameters as possible biomarkers of bacterial septic arthritis (SA). Materials and methods: We prospectively examined adult patients with SA. As a control group, adults with uninfected joints were enrolled. SF samples were obtained, and microbiological analyses were made. SF glucose levels, pH, and leukocyte esterase were measured using a glucometer and colorimetric test strips. Blood samples were collected from both groups to determine glucose levels. Results: We included eight subjects with knee ligaments lesions, six with meniscus lesions, and five with osteoarthritis as the control group, as well as 20 patients with SA. SF culture was positive in 60%. SF glucose levels from patients were lower than the controls (p = 0.0018) with the lowest concentration in patients with a positive culture (p = 0.0004). Blood and SF glucose concentration from the positive culture patients were compared (p < 0.0001). Leukocyte esterase presented the highest values in patients with a positive culture (p < 0.0001) and a more acidic pH was found compared to the control group (p < 0.0001). Conclusion: These biochemical parameters might be a quick and inexpensive added value for distinguishing between infective and non-infective joint disease. |
| format | Article |
| id | eprints-30021 |
| institution | UANL |
| language | English |
| publishDate | 2022 |
| publisher | Academia Mexicana de Cirugía |
| record_format | eprints |
| spelling | eprints-300212025-07-16T15:57:27Z http://eprints.uanl.mx/30021/ Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis González Chapa, Jorge A. Peña Martínez, Víctor Manuel González, Gloria M. Vílchez Cavazos, José Félix Treviño Rangel, Rogelio J. Salinas Carmona, Mario César Rosas Taraco, Adrian G. RC Medicina Interna, Psiquiatría, Neurología Objective: The objective of the study was to determine the added value of synovial fluid (SF) glucose levels and other biochemical parameters as possible biomarkers of bacterial septic arthritis (SA). Materials and methods: We prospectively examined adult patients with SA. As a control group, adults with uninfected joints were enrolled. SF samples were obtained, and microbiological analyses were made. SF glucose levels, pH, and leukocyte esterase were measured using a glucometer and colorimetric test strips. Blood samples were collected from both groups to determine glucose levels. Results: We included eight subjects with knee ligaments lesions, six with meniscus lesions, and five with osteoarthritis as the control group, as well as 20 patients with SA. SF culture was positive in 60%. SF glucose levels from patients were lower than the controls (p = 0.0018) with the lowest concentration in patients with a positive culture (p = 0.0004). Blood and SF glucose concentration from the positive culture patients were compared (p < 0.0001). Leukocyte esterase presented the highest values in patients with a positive culture (p < 0.0001) and a more acidic pH was found compared to the control group (p < 0.0001). Conclusion: These biochemical parameters might be a quick and inexpensive added value for distinguishing between infective and non-infective joint disease. Academia Mexicana de Cirugía 2022 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/30021/1/1368.pdf http://eprints.uanl.mx/30021/1.haspreviewThumbnailVersion/1368.pdf González Chapa, Jorge A. y Peña Martínez, Víctor Manuel y González, Gloria M. y Vílchez Cavazos, José Félix y Treviño Rangel, Rogelio J. y Salinas Carmona, Mario César y Rosas Taraco, Adrian G. (2022) Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis. Cirugía y Cirujanos, 90 (3). pp. 319-331. ISSN 0009-7411 http://doi.org/10.24875/CIRU.20001347 doi:10.24875/CIRU.20001347 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología González Chapa, Jorge A. Peña Martínez, Víctor Manuel González, Gloria M. Vílchez Cavazos, José Félix Treviño Rangel, Rogelio J. Salinas Carmona, Mario César Rosas Taraco, Adrian G. Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis |
| title_full | Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis |
| title_fullStr | Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis |
| title_full_unstemmed | Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis |
| title_short | Glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis |
| title_sort | glucose and leukocyte esterase levels are possible biomarkers for bacterial septic arthritis |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/30021/1/1368.pdf |
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