Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?

Obesity has reached epidemic proportions particularly in western countries. Most non-surgical treatments of this condition are disappointing. Since 2005, several studies evaluating the effect of Botulinum Toxin type A (BT-A) in gastric antrum by means of endoscopy for the treatment of obesity have b...

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Autores principales: García Compeán, Diego, Garza, Hector Maldonado
Formato: Artículo
Lenguaje:inglés
Publicado: Baishideng Publishing Group 2008
Acceso en línea:http://eprints.uanl.mx/29908/1/29908.pdf
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author García Compeán, Diego
Garza, Hector Maldonado
author_facet García Compeán, Diego
Garza, Hector Maldonado
author_sort García Compeán, Diego
collection Repositorio Institucional
description Obesity has reached epidemic proportions particularly in western countries. Most non-surgical treatments of this condition are disappointing. Since 2005, several studies evaluating the effect of Botulinum Toxin type A (BT-A) in gastric antrum by means of endoscopy for the treatment of obesity have been published. This treatment modality was based on the observation that gastric injection of BT-A in laparatomized rats induced a significant reduction of food intake and body weight. Nowadays, 6 studies have been published yielding conflicting results. Differences in selection of patients, doses of BT-A, method of administration of the toxin and instruments of evaluation of some parameters among these studies may be the cause of divergent results. We discuss herein some important features of these studies pointing out on differences among them. At the same time, based on the knowledge of physiological characteristics of normal and abnormal gastric function related with feeding, we discuss the probable causes of failure observed in these trials. Finally, we give some guidelines concerning the way that future research in this field may follow, not without calling attention to disadvantages of this treatment.
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spelling eprints-299082025-07-04T15:36:36Z http://eprints.uanl.mx/29908/ Intragastric injection of botulinum toxin for the treatment of obesity. Where are we? García Compeán, Diego Garza, Hector Maldonado Obesity has reached epidemic proportions particularly in western countries. Most non-surgical treatments of this condition are disappointing. Since 2005, several studies evaluating the effect of Botulinum Toxin type A (BT-A) in gastric antrum by means of endoscopy for the treatment of obesity have been published. This treatment modality was based on the observation that gastric injection of BT-A in laparatomized rats induced a significant reduction of food intake and body weight. Nowadays, 6 studies have been published yielding conflicting results. Differences in selection of patients, doses of BT-A, method of administration of the toxin and instruments of evaluation of some parameters among these studies may be the cause of divergent results. We discuss herein some important features of these studies pointing out on differences among them. At the same time, based on the knowledge of physiological characteristics of normal and abnormal gastric function related with feeding, we discuss the probable causes of failure observed in these trials. Finally, we give some guidelines concerning the way that future research in this field may follow, not without calling attention to disadvantages of this treatment. Baishideng Publishing Group 2008 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/29908/1/29908.pdf http://eprints.uanl.mx/29908/1.haspreviewThumbnailVersion/29908.pdf García Compeán, Diego y Garza, Hector Maldonado (2008) Intragastric injection of botulinum toxin for the treatment of obesity. Where are we? World Journal of Gastroenterology, 14 (12). pp. 1805-1809. ISSN 1007-9327 http://doi.org/10.3748/wjg.14.1805 doi:10.3748/wjg.14.1805
spellingShingle García Compeán, Diego
Garza, Hector Maldonado
Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?
title_full Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?
title_fullStr Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?
title_full_unstemmed Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?
title_short Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?
title_sort intragastric injection of botulinum toxin for the treatment of obesity where are we
url http://eprints.uanl.mx/29908/1/29908.pdf
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