CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value
Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of pa...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Taylor and Francis
2012
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| Acceso en línea: | http://eprints.uanl.mx/29788/7/29788.pdf |
| _version_ | 1838551023042428928 |
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| author | Solano Genesta, Manuel Tarín Arzaga, Luz Velasco Ruiz, Ileana Lutz Presno, Julia A. González Llano, Óscar Mancías Guerra, Consuelo Rodríguez Romo, Laura Ruiz Delgado, Guillermo J. Ruiz Argüelles, Guillermo José Jaime Pérez, José Carlos Gómez Almaguer, David |
| author_facet | Solano Genesta, Manuel Tarín Arzaga, Luz Velasco Ruiz, Ileana Lutz Presno, Julia A. González Llano, Óscar Mancías Guerra, Consuelo Rodríguez Romo, Laura Ruiz Delgado, Guillermo J. Ruiz Argüelles, Guillermo José Jaime Pérez, José Carlos Gómez Almaguer, David |
| author_sort | Solano Genesta, Manuel |
| collection | Repositorio Institucional |
| description | Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of patients at diagnosis. There was no correlation between CD20 expression and age, white blood cell count, or cytogenetic abnormalities. Despite the fact that CD20-positive ALL patients had a tendency toward a worse outcome, there was no significant difference between patients with and without CD20 expression in 3-year overall survival 65 vs. 82% (P = 0.14), and cumulative incidence of relapse 36 vs. 18% (P = 0.3) in pediatric patients and 51 vs. 53% (P = 0.31) and 35 vs. 38% (P = 0.6) in adults, respectively. In conclusion, CD20 expression appears to be more common in Mexican patients with newly diagnosed precursor B-cell ALL higher than in Caucasian populations and lacks prognostic value. |
| format | Article |
| id | eprints-29788 |
| institution | UANL |
| language | English |
| publishDate | 2012 |
| publisher | Taylor and Francis |
| record_format | eprints |
| spelling | eprints-297882025-07-23T14:26:59Z http://eprints.uanl.mx/29788/ CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value Solano Genesta, Manuel Tarín Arzaga, Luz Velasco Ruiz, Ileana Lutz Presno, Julia A. González Llano, Óscar Mancías Guerra, Consuelo Rodríguez Romo, Laura Ruiz Delgado, Guillermo J. Ruiz Argüelles, Guillermo José Jaime Pérez, José Carlos Gómez Almaguer, David Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of patients at diagnosis. There was no correlation between CD20 expression and age, white blood cell count, or cytogenetic abnormalities. Despite the fact that CD20-positive ALL patients had a tendency toward a worse outcome, there was no significant difference between patients with and without CD20 expression in 3-year overall survival 65 vs. 82% (P = 0.14), and cumulative incidence of relapse 36 vs. 18% (P = 0.3) in pediatric patients and 51 vs. 53% (P = 0.31) and 35 vs. 38% (P = 0.6) in adults, respectively. In conclusion, CD20 expression appears to be more common in Mexican patients with newly diagnosed precursor B-cell ALL higher than in Caucasian populations and lacks prognostic value. Taylor and Francis 2012-03 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/29788/7/29788.pdf http://eprints.uanl.mx/29788/7.haspreviewThumbnailVersion/29788.pdf Solano Genesta, Manuel y Tarín Arzaga, Luz y Velasco Ruiz, Ileana y Lutz Presno, Julia A. y González Llano, Óscar y Mancías Guerra, Consuelo y Rodríguez Romo, Laura y Ruiz Delgado, Guillermo J. y Ruiz Argüelles, Guillermo José y Jaime Pérez, José Carlos y Gómez Almaguer, David (2012) CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value. Hematology, 17 (2). pp. 66-70. ISSN 1607-8454 doi:10.1179/102453312X13221316477741 |
| spellingShingle | Solano Genesta, Manuel Tarín Arzaga, Luz Velasco Ruiz, Ileana Lutz Presno, Julia A. González Llano, Óscar Mancías Guerra, Consuelo Rodríguez Romo, Laura Ruiz Delgado, Guillermo J. Ruiz Argüelles, Guillermo José Jaime Pérez, José Carlos Gómez Almaguer, David CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value |
| title_full | CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value |
| title_fullStr | CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value |
| title_full_unstemmed | CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value |
| title_short | CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value |
| title_sort | cd20 expression in b cell precursor acute lymphoblastic leukemia is common in mexican patients and lacks a prognostic value |
| url | http://eprints.uanl.mx/29788/7/29788.pdf |
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