Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach
Plant-derived miRNAs can be found in the human body after dietary intake, and they can affect post-transcriptional gene regulation in human. It is important to identify targets to determine the possible effects in human genes by using computational approach. In this study, 787 possible mRNAs human t...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
KeAi Communications
2022
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/27827/1/27827.pdf |
| _version_ | 1824420833609646080 |
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| author | Sánchez Romo, Daniel Hernández Vásquez, César Ignacio Pereyra Alférez, Benito García García, Jorge Hugo |
| author_facet | Sánchez Romo, Daniel Hernández Vásquez, César Ignacio Pereyra Alférez, Benito García García, Jorge Hugo |
| author_sort | Sánchez Romo, Daniel |
| collection | Repositorio Institucional |
| description | Plant-derived miRNAs can be found in the human body after dietary intake, and they can affect post-transcriptional gene regulation in human. It is important to identify targets to determine the possible effects in human genes by using computational approach. In this study, 787 possible mRNAs human targets were predicted by 84 miRNAs of wheat. A total of 14 miRNAs were identified with individual binding to 33 mRNAs associated with schizophrenia, epilepsy, neurodevelopmental disorders, and various cancers, located in the 3′UTR of the mRNA. A functional enrichment was carried out, where the results showed associations to pathways such as dopaminergic synapse (hsa04728), and signaling pathways, significantly associated with the target genes. The prediction of target mRNAs in humans by wheat miRNAs, offer candidates that could facilitate the search and verification, which could be of relevance for future projects and there for contribute in the therapeutic treatment of various human diseases. |
| format | Article |
| id | eprints-27827 |
| institution | UANL |
| language | English |
| publishDate | 2022 |
| publisher | KeAi Communications |
| record_format | eprints |
| spelling | eprints-278272024-12-11T17:15:04Z http://eprints.uanl.mx/27827/ Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach Sánchez Romo, Daniel Hernández Vásquez, César Ignacio Pereyra Alférez, Benito García García, Jorge Hugo QR Microbiología Plant-derived miRNAs can be found in the human body after dietary intake, and they can affect post-transcriptional gene regulation in human. It is important to identify targets to determine the possible effects in human genes by using computational approach. In this study, 787 possible mRNAs human targets were predicted by 84 miRNAs of wheat. A total of 14 miRNAs were identified with individual binding to 33 mRNAs associated with schizophrenia, epilepsy, neurodevelopmental disorders, and various cancers, located in the 3′UTR of the mRNA. A functional enrichment was carried out, where the results showed associations to pathways such as dopaminergic synapse (hsa04728), and signaling pathways, significantly associated with the target genes. The prediction of target mRNAs in humans by wheat miRNAs, offer candidates that could facilitate the search and verification, which could be of relevance for future projects and there for contribute in the therapeutic treatment of various human diseases. KeAi Communications 2022-06 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/27827/1/27827.pdf http://eprints.uanl.mx/27827/1.haspreviewThumbnailVersion/27827.pdf Sánchez Romo, Daniel y Hernández Vásquez, César Ignacio y Pereyra Alférez, Benito y García García, Jorge Hugo (2022) Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach. Non-coding RNA Research, 7 (2). pp. 89-97. ISSN 2468-0540 https://www.sciencedirect.com/science/article/pii/S246805402200021X?via%3Dihub doi:10.1016/j.ncrna.2022.03.002 |
| spellingShingle | QR Microbiología Sánchez Romo, Daniel Hernández Vásquez, César Ignacio Pereyra Alférez, Benito García García, Jorge Hugo Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach |
| title_full | Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach |
| title_fullStr | Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach |
| title_full_unstemmed | Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach |
| title_short | Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: a cross kingdom computational approach |
| title_sort | identification of potential target genes in homo sapiens by mirna of triticum aestivum a cross kingdom computational approach |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/27827/1/27827.pdf |
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