Effects of pericytes and colon cancer stem cells in the tumor microenvironment
Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, most CRC, despite responding favorably to treatment, develop resistance and present recurren...
| Autores principales: | , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Springer Nature
2019
|
| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/27824/7/27824.pdf |
| _version_ | 1824420832899760128 |
|---|---|
| author | Garza Treviño, Elsa Nancy Delgado González, Paulina Valencia Salgado, Carlos I. Martínez Garza, Alejandra Mayela |
| author_facet | Garza Treviño, Elsa Nancy Delgado González, Paulina Valencia Salgado, Carlos I. Martínez Garza, Alejandra Mayela |
| author_sort | Garza Treviño, Elsa Nancy |
| collection | Repositorio Institucional |
| description | Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, most CRC, despite responding favorably to treatment, develop resistance and present recurrence, a situation that will inevitably lead to death. In recent years, it has been shown that the main reason for drug resistance is the presence of colon cancer stem cells (CSC). Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME), contributing to the formation of vessels and promoting metastasis; however, they have not been considered very important as a therapeutic target in cancer. In this review, we highlight the contribution of pericytes and cancer stem cells to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss therapies targeting pericytes and cancer stem cells in CRC. |
| format | Article |
| id | eprints-27824 |
| institution | UANL |
| language | English |
| publishDate | 2019 |
| publisher | Springer Nature |
| record_format | eprints |
| spelling | eprints-278242024-12-09T20:55:13Z http://eprints.uanl.mx/27824/ Effects of pericytes and colon cancer stem cells in the tumor microenvironment Garza Treviño, Elsa Nancy Delgado González, Paulina Valencia Salgado, Carlos I. Martínez Garza, Alejandra Mayela RC Medicina Interna, Psiquiatría, Neurología Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, most CRC, despite responding favorably to treatment, develop resistance and present recurrence, a situation that will inevitably lead to death. In recent years, it has been shown that the main reason for drug resistance is the presence of colon cancer stem cells (CSC). Pericytes are also capable of tumor homing and are important cellular components of the tumor microenvironment (TME), contributing to the formation of vessels and promoting metastasis; however, they have not been considered very important as a therapeutic target in cancer. In this review, we highlight the contribution of pericytes and cancer stem cells to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss therapies targeting pericytes and cancer stem cells in CRC. Springer Nature 2019-07-01 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/27824/7/27824.pdf http://eprints.uanl.mx/27824/7.haspreviewThumbnailVersion/27824.pdf Garza Treviño, Elsa Nancy y Delgado González, Paulina y Valencia Salgado, Carlos I. y Martínez Garza, Alejandra Mayela (2019) Effects of pericytes and colon cancer stem cells in the tumor microenvironment. Cancer Cell International, 19 (1). pp. 1-12. ISSN 1475-2867 https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0888-9 doi:10.1186/s12935-019-0888-9 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Garza Treviño, Elsa Nancy Delgado González, Paulina Valencia Salgado, Carlos I. Martínez Garza, Alejandra Mayela Effects of pericytes and colon cancer stem cells in the tumor microenvironment |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Effects of pericytes and colon cancer stem cells in the tumor microenvironment |
| title_full | Effects of pericytes and colon cancer stem cells in the tumor microenvironment |
| title_fullStr | Effects of pericytes and colon cancer stem cells in the tumor microenvironment |
| title_full_unstemmed | Effects of pericytes and colon cancer stem cells in the tumor microenvironment |
| title_short | Effects of pericytes and colon cancer stem cells in the tumor microenvironment |
| title_sort | effects of pericytes and colon cancer stem cells in the tumor microenvironment |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/27824/7/27824.pdf |
| work_keys_str_mv | AT garzatrevinoelsanancy effectsofpericytesandcoloncancerstemcellsinthetumormicroenvironment AT delgadogonzalezpaulina effectsofpericytesandcoloncancerstemcellsinthetumormicroenvironment AT valenciasalgadocarlosi effectsofpericytesandcoloncancerstemcellsinthetumormicroenvironment AT martinezgarzaalejandramayela effectsofpericytesandcoloncancerstemcellsinthetumormicroenvironment |